Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD).
Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD).
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DOI：
10.3390/jcm10143098
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发表时间：
2021-07-14
影响因子：
3.9
通讯作者：
Nabeshima S
中科院分区：
文献类型：
--
作者：
Okutsu S;Kato Y;Funakoshi S;Maeda T;Yoshimura C;Kawazoe M;Satoh A;Yokota S;Tada K;Takahashi K;Ito K;Yasuno T;Fujii H;Mukoubara S;Nakashima H;Kawanami D;Masutani K;Arima H;Nabeshima S
本研究的目的是调查日本普通人群中从 20 岁起长期体重增加对高低密度脂蛋白 (LDL) 胆固醇血症发生率的影响。方法：我们利用日本长崎县壹岐市居民的年度健康检查数据进行了一项基于人群的回顾性队列研究。共有 3179 名基线时没有高 LDL 胆固醇血症、接受过两次或多次健康检查的成年（≥30 岁）男性和女性纳入分析。通过问卷调查获得20岁后体重增加（≥10公斤）的信息。本研究的结果是发生高 LDL 胆固醇血症（定义为 LDL 胆固醇水平≥3.62 mmol/L 和/或开始使用降脂药物）。结果：在平均 4.53 年的随访期间，3179 名参与者中有 665 人出现高 LDL 胆固醇血症（46.5/1000 人年）。体重增加≥10公斤的参与者（55.3/1000人年）的高LDL胆固醇血症发生率高于体重增加<10公斤的参与者（41.8/1000人年）。即使在调整年龄、性别、吸烟、每日饮酒、运动、肥胖、高血压和糖尿病后，这种关联仍然具有统计学意义（多变量风险比 1.31，95% 置信区间 1.08–1.58，p = 0.006）。结论：在日本普通人群中，无论年龄、性别和肥胖程度如何，20 岁后体重增加 ≥10 都会影响高 LDL 胆固醇的发展。
The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, p = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese.
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影响因子：
37.8
作者：
Jensen MD;Ryan DH;Apovian CM;Ard JD;Comuzzie AG;Donato KA;Hu FB;Hubbard VS;Jakicic JM;Kushner RF;Loria CM;Millen BE;Nonas CA;Pi-Sunyer FX;Stevens J;Stevens VJ;Wadden TA;Wolfe BM;Yanovski SZ;Jordan HS;Kendall KA;Lux LJ;Mentor-Marcel R;Morgan LC;Trisolini MG;Wnek J;Anderson JL;Halperin JL;Albert NM;Bozkurt B;Brindis RG;Curtis LH;DeMets D;Hochman JS;Kovacs RJ;Ohman EM;Pressler SJ;Sellke FW;Shen WK;Smith SC Jr;Tomaselli GF;American College of Cardiology/American Heart Association Task Force on Practice Guidelines;Obesity Society
通讯作者：
Obesity Society
影响因子：
4.2
作者：
Bjornstad P;Eckel RH
通讯作者：
Eckel RH
影响因子：
4.5
作者：
Zmysłowski A;Szterk A
通讯作者：
Szterk A
影响因子：
3.7
作者：
Ishida S;Kondo S;Funakoshi S;Satoh A;Maeda T;Kawazoe M;Yoshimura C;Tada K;Takahashi K;Ito K;Yasuno T;Masutani K;Nakashima H;Arima H
通讯作者：
Arima H
影响因子：
5.6
作者：
Jung UJ;Choi MS
通讯作者：
Choi MS