Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.
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DOI：
10.3390/ijms15046184
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发表时间：
2014-04-11
影响因子：
5.6
通讯作者：
Choi MS
中科院分区：
文献类型：
--
作者：
Jung UJ;Choi MS
越来越多的证据表明，肥胖与胰岛素抵抗、2型糖尿病、血脂异常和非酒精性脂肪肝等代谢性疾病的风险增加密切相关。肥胖是由于食物摄入和能量消耗之间的不平衡，这导致脂肪组织的过度积累。脂肪组织现在不仅被认为是储存来自食物摄入的多余能量的主要场所，而且被认为是内分泌器官。脂肪组织的扩张产生许多生物活性物质，称为脂肪细胞因子或脂肪因子，其触发慢性低度炎症并与许多不同器官中的一系列过程相互作用。虽然确切的机制尚不清楚，但由过量脂肪组织和脂肪组织功能障碍引起的这些脂肪因子的产生或分泌失调可有助于肥胖相关代谢疾病的发展。本文就几种脂肪因子在肥胖中的作用及其对肥胖相关代谢疾病的影响作一综述。多线证据提供了有价值的见解脂肪因子在肥胖及其代谢并发症的发展中的作用。进一步的研究仍然需要充分了解一些新发现的脂肪因子的代谢作用的机制。
Accumulating evidence indicates that obesity is closely associated with an increased risk of metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver disease. Obesity results from an imbalance between food intake and energy expenditure, which leads to an excessive accumulation of adipose tissue. Adipose tissue is now recognized not only as a main site of storage of excess energy derived from food intake but also as an endocrine organ. The expansion of adipose tissue produces a number of bioactive substances, known as adipocytokines or adipokines, which trigger chronic low-grade inflammation and interact with a range of processes in many different organs. Although the precise mechanisms are still unclear, dysregulated production or secretion of these adipokines caused by excess adipose tissue and adipose tissue dysfunction can contribute to the development of obesity-related metabolic diseases. In this review, we focus on the role of several adipokines associated with obesity and the potential impact on obesity-related metabolic diseases. Multiple lines evidence provides valuable insights into the roles of adipokines in the development of obesity and its metabolic complications. Further research is still required to fully understand the mechanisms underlying the metabolic actions of a few newly identified adipokines.
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