The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.
The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.
复制标题
核因子-kappaB通路在重症新冠肺炎患者中的作用及治疗潜力
DOI：
10.1007/s10787-020-00773-9
复制
发表时间：
2021-03
影响因子：
5.8
通讯作者：
Rela M
中科院分区：
文献类型：
--
作者：
Hariharan A;Hakeem AR;Radhakrishnan S;Reddy MS;Rela M
2019冠状病毒病（COVID-19）大流行影响了全球的医疗保健系统。COVID-19的严重表现，如严重肺炎和急性呼吸窘迫综合征（ARDS），与病毒后激活和释放细胞因子/趋化因子有关，导致“细胞因子风暴”，引起炎症反应和破坏，主要影响肺部。COVID-19激活各种细胞如肺、肝、肾、中枢神经系统、胃肠道系统和心血管系统的巨噬细胞中的转录因子NF-κ B（NF-κB），导致产生IL-1、IL-2、IL-6、IL-12、TNF-α、LT-α、LT-β、GM-CSF和各种趋化因子。在老年人和代谢综合征患者中，敏感的NF-κB使这类人群容易感染COVID-19及其更严重的并发症，包括更高的死亡率。NF-κB活化水平的免疫调节和NF-κB（IκB）降解抑制剂沿着TNF-α抑制，可能导致细胞因子风暴减少，并减轻COVID-19的严重程度。抑制NF-κB通路在缓解严重形式的COVID-19方面具有潜在的治疗作用。
Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and release of cytokine/chemokines which leads to a “cytokine storm” causing inflammatory response and destruction, mainly affecting the lungs. COVID-19 activation of transcription factor, NF-kappa B (NF-κB) in various cells such as macrophages of lung, liver, kidney, central nervous system, gastrointestinal system and cardiovascular system leads to production of IL-1, IL-2, IL-6, IL-12, TNF-α, LT-α, LT-β, GM-CSF, and various chemokines. The sensitised NF-κB in elderly and in patients with metabolic syndrome makes this set of population susceptible to COVID-19 and their worse complications, including higher mortality. Immunomodulation at the level of NF-κB activation and inhibitors of NF-κB (IκB) degradation along with TNF-α inhibition will potentially result in a reduction in the cytokine storm and alleviate the severity of COVID-19. Inhibition of NF-κB pathway has a potential therapeutic role in alleviating the severe form of COVID-19.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
29
作者：
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通讯作者：
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影响因子：
9
作者：
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影响因子：
11.2
作者：
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通讯作者：
Anderson, Robin L.
影响因子：
56.9
作者：
AUPHAN, N;DIDONATO, JA;KARIN, M
通讯作者：
KARIN, M