Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats.
Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats.
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DOI：
10.1016/j.physbeh.2011.10.001
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发表时间：
2012-02-01
影响因子：
2.9
通讯作者：
Neisewander JL
中科院分区：
文献类型：
--
作者：
Peartree NA;Hood LE;Thiel KJ;Sanabria F;Pentkowski NS;Chandler KN;Neisewander JL
青春期是一个对社会影响更加敏感和更易受药物滥用影响的时期。青少年大鼠的社会奖励已经用条件性位置偏好（CPP）模型得到了证实，但不清楚与另一只大鼠的有限接触是否足以产生奖励。我们使用包含两个主隔室的装置研究了这个问题，每个隔室都有一个金属丝网屏障，允许放置在屏障两侧的大鼠进行有限的身体接触。在基线偏好测试后，对青春期雄性大鼠每天进行两次条件训练，持续2天或8天。将大鼠单独置于它们的优选侧，每天10分钟，并置于它们最初的非优选侧（即，CS），在此期间，它们可以限制或不受限制地物理接触另一只大鼠（分别为Rat/Mesh或Rat/Phys）或网球（分别为Ball/Mesh或Ball/Phys）无条件刺激（US）。仅大鼠/Phys组在2次CS-US配对后显示CPP;然而，在8次CS-US配对后，大鼠/补片和球/Phys组也显示CPP。在条件反射过程中，与球相比，大鼠US引起了更强大的方法和接触行为，无论物理或限制访问。接触和/或接近的发生率随着接触次数的增加而增加。结果表明，US奖赏效应的大小顺序为与大鼠的身体接触>与大鼠的有限接触>与球的身体接触，而打闹游戏并不是建立社会性奖赏-CPP的必要条件。这一发现对新兴的药物自我给药模型具有重要意义，在该模型中，两只大鼠通过静脉内自我给药，通过各自操作性条件反射室之间共享的网状屏障进行有限的物理接触。
Adolescence is a period of enhanced sensitivity to social influences and vulnerability to drug abuse. Social reward in adolescent rats has been demonstrated with the conditioned place preference (CPP) model, but it is not clear whether limited contact with another rat without play is sufficient to produce reward. We investigated this issue using an apparatus containing two main compartments each with a wire mesh barrier that allowed rats placed on either side of the barrier to have limited physical contact. Adolescent male rats were given two conditioning sessions/day for 2 or 8 days following baseline preference tests. Rats were placed into their preferred side alone for one daily 10-min session and into their initially non-preferred side (i.e., CS) for the other session during which they either had restricted or unrestricted physical access to another rat (Rat/Mesh or Rat/Phys, respectively) or to a tennis ball (Ball/Mesh or Ball/Phys, respectively) unconditioned stimulus (US). Only the Rat/Phys group exhibited CPP after 2 CS-US pairings; however, after 8 CS-US pairings, the Rat/Mesh and Ball/Phys groups also exhibited CPP. During conditioning, the rat US elicited more robust approach and contact behavior compared to the ball, regardless of physical or restricted access. The incidence of contact and/or approach increased as the number of exposures increased. The results suggest that the rank order of US reward efficacy was physical contact with a rat > limited contact with a rat > physical contact with a ball, and that rough-and-tumble play is not necessary to establish social reward-CPP. The findings have important implications for emerging drug self-administration models in which two rats self-administering drug intravenously have limited physical contact via a mesh barrier shared between their respective operant conditioning chambers.
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影响因子：
3.6
作者：
Cao, Junran;Belluzzi, James D.;Loughlin, Sandra E.;Dao, Jasmin M.;Chen, YiLing;Leslie, Frances M.
通讯作者：
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作者：
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通讯作者：
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