Gut Microbial and Metabolic Profiling Reveal the Lingering Effects of Infantile Iron Deficiency Unless Treated with Iron.
Gut Microbial and Metabolic Profiling Reveal the Lingering Effects of Infantile Iron Deficiency Unless Treated with Iron.
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DOI：
10.1002/mnfr.202001018
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发表时间：
2021-04
影响因子：
5.2
通讯作者：
Swann JR
中科院分区：
文献类型：
--
作者：
Mayneris-Perxachs J;Amaral W;Lubach GR;Lyte M;Phillips GJ;Posma JM;Coe CL;Swann JR
缺铁(ID)危害全世界婴儿的健康。尽管铁可以很容易地治疗，但人们仍然担心一些影响的持久性。本文研究了幼猴缺铁自然恢复后和用右旋糖酐铁和维生素B治疗后的代谢和肠道微生物的影响。用~1H核磁共振波谱分析尿液和血浆的代谢组谱。通过16S rRNA基因的扩增序列测定直肠拭子中的肠道微生物区系。PID猴的尿代谢谱明显不同于PID+Fe和持续铁充足对照组(IS)，它们的麦芽糖含量较高，微生物衍生代谢物的数量较少。持续的能量代谢差异从血浆代谢表型中明显可见，在更大程度上依赖于无氧糖酵解。微生物图谱显示，与IS对照组相比，ID组猴子体内甲烷短杆菌、乳杆菌和瘤胃球菌的丰度较高，而ID病史导致普氏杆菌丰度较低。在ID自然恢复后，发现了挥之不去的代谢和微生物效应。这些长期的生化紊乱在PID+Fe动物中不存在，强调了早期发现和治疗ID的重要性，以改善其慢性代谢效应。缺铁性贫血是全世界普遍关注的营养和儿科问题。除了对红细胞的已知影响外，铁对氧化代谢和合成途径也有不同的影响。在这项研究中，观察了从婴儿缺铁症自然恢复的幼猴体内挥之不去的代谢和肠道微生物紊乱。通过使用右旋糖苷铁和维生素B快速治疗早期铁缺乏症，可以防止这些持续的代谢影响。这些发现突显了在生命早期识别和治疗婴儿缺铁的重要性。
Iron deficiency (ID) compromises the health of infants worldwide. Although readily treated with iron, concerns remain about the persistence of some effects. Metabolic and gut microbial consequences of infantile ID were investigated in juvenile monkeys after natural recovery (pID) from iron deficiency or post-treatment with iron dextran and B vitamins (pID+Fe). Metabolomic profiling of urine and plasma was conducted with 1H nuclear magnetic resonance (NMR) spectroscopy. Gut microbiota were characterized from rectal swabs by amplicon sequencing of the 16S rRNA gene. Urinary metabolic profiles of pID monkeys significantly differed from pID+Fe and continuously iron-sufficient controls (IS) with higher maltose and lower amounts of microbial-derived metabolites. Persistent differences in energy metabolism were apparent from the plasma metabolic phenotypes with greater reliance on anaerobic glycolysis in pID monkeys. Microbial profiling indicated higher abundances of Methanobrevibacter, Lachnobacterium and Ruminococcus in pID monkeys and any history of ID resulted in a lower Prevotella abundance compared to the IS controls. Lingering metabolic and microbial effects were found after natural recovery from ID. These long-term biochemical derangements were not present in the pID+Fe animals emphasizing the importance of the early detection and treatment of early-life ID to ameliorate its chronic metabolic effects. Iron deficiency anemia is a common nutritional and pediatric concern worldwide. In addition to the known effects on red blood cells, iron has diverse effects on oxidative metabolism and synthesis pathways. In this study, lingering metabolic and gut microbial disruptions were observed in juvenile monkeys that had naturally recovery from infantile iron deficiency. These persistent metabolic effects were prevented with the rapid treatment of early-life iron deficiency with iron dextran and B vitamins. These findings highlight the importance of identifying and treating infantile iron deficiency early in life.
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