Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs.
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs.
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DOI：
10.3390/nu10050632
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发表时间：
2018-05-17
期刊：
影响因子：
5.9
通讯作者：
Dilger RN
中科院分区：
文献类型：
--
作者：
Knight LC;Dilger RN
缺铁是世界上最常见的营养素缺乏症。由于快速生长，婴儿特别容易患缺铁症，如果不治疗，很容易发展为缺铁性贫血（IDA）。本研究的目的是确定早期生活铁缺乏症的持久影响后，一段时间的饮食铁补充。从出生后第2天（PND）至第32天（第1阶段），42头健康雄性猪自由采食对照组（CONT，21.3 mg Fe/L）或缺铁组（ID 2.72 mg Fe/L）的牛奶。从PND 33至61（第2阶段），所有猪均过渡到一系列行业标准的铁充足饲料。从PND 7至28每周采集一次血液，并在PND 35和56再次采集，在PND 32或PND 61采集组织。在第1阶段结束时，ID猪与CONT猪相比表现出降低的红细胞压积（Hct; p <0.0001）和血红蛋白（Hb; p < 0.0001），但在第2阶段结束时，在饮食铁补充后，治疗组之间的Hct（p = 0.5968）和Hb（p = 0.6291）均无差异。在第1阶段期间，与CONT猪相比，ID猪在PND 32时的体重增加减少（p < 0.0001）58%，并且该效应在第2阶段结束时仍然显著（p = 0.0001），在PND 61时ID猪的体重比CONT猪低34%。外周蛋白质和信使RNA（mRNA）基因表达生物标志物的分析产生了不确定的结果，这与基于多个种属的既往生物标志物分析的预期一致。这些研究结果表明，早期生活中的铁状态对血液参数和生长性能产生负面影响，膳食铁补充可以完全恢复血液学结果，但不能恢复生长性能。
Iron deficiency is reported as the most common nutrient deficiency worldwide. Due to rapid growth, infants are at particular risk for developing iron deficiency, which can easily progress to iron deficiency anemia (IDA), if not treated. The aim of this study was to determine the lasting effects of an early-life iron deficiency after a period of dietary iron repletion. Forty-two intact male pigs were fed, ad libitum, either control (CONT, 21.3 mg Fe/L) or iron-deficient (ID 2.72 mg Fe/L) milk replacer from postnatal day (PND) 2 to 32 (phase 1). From PND 33 to 61 (phase 2), all pigs were transitioned onto a series of industry-standard, iron-adequate diets. Blood was collected weekly from PND 7 to 28, and again on PND 35 and 56, and tissues were collected at either PND 32 or PND 61. At the end of phase 1, ID pigs exhibited reduced hematocrit (Hct; p < 0.0001) and hemoglobin (Hb; p < 0.0001) compared with CONT pigs, but neither Hct (p = 0.5968) nor Hb (p = 0.6291) differed between treatment groups after dietary iron repletion at the end of phase 2. Body weight gain was reduced (p < 0.0001) 58% at PND 32 in ID pigs compared with CONT pigs during phase 1, and this effect remained significant at the end of phase 2 (p = 0.0001), with ID pigs weighing 34% less than CONT pigs at PND 61. Analysis of peripheral protein and messenger RNA (mRNA) gene expression biomarkers yielded inconclusive results, as would be expected based on previous biomarker analyses across multiple species. These findings suggest that early-life iron status negatively influences blood parameters and growth performance, with dietary iron repletion allowing for full recovery of hematological outcomes, but not growth performance.
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DOI：
10.1007/978-1-59745-462-9_5
发表时间：
2010-01-01
期刊：
IRON DEFICIENCY AND OVERLOAD
影响因子：
--
作者：
Hagemann, Tracy M.;Lewis, Teresa V.
通讯作者：
Lewis, Teresa V.
DOI：
10.1196/annals.1365.026
发表时间：
2006-01-01
期刊：
WOMEN'S HEALTH AND DISEASE: GYNECOLOGIC, ENDOCRINE, AND REPRODUCTIVE ISSUES
影响因子：
--
作者：
Malamitsi-Puchner, Ariadne;Nikolaou, K. E.;Puchner, K-P.
通讯作者：
Puchner, K-P.
影响因子：
3.9
作者：
Branca, F;Ferrari, M
通讯作者：
Ferrari, M
影响因子：
--
作者：
Bauer, R;Walter, B;Zwiener, U
通讯作者：
Zwiener, U
影响因子：
3.7
作者：
Eiby, Yvonne A.;Wright, Layne L.;Lingwood, Barbara E.
通讯作者：
Lingwood, Barbara E.