Association of plasma neutrophil gelatinase-associated lipocalin and thoracic aorta calcification in maintenance hemodialysis patients with and without diabetes.
Association of plasma neutrophil gelatinase-associated lipocalin and thoracic aorta calcification in maintenance hemodialysis patients with and without diabetes.
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血浆中性粒细胞明胶酶相关脂质运载蛋白与伴或不伴糖尿病的维持性血液透析患者胸主动脉钙化的相关性。
DOI：
10.1186/s12882-022-02773-z
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发表时间：
2022-04-22
期刊：
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
中性粒细胞明胶酶相关脂质运载蛋白（NGAL）不仅是一种参与代谢的骨源性因子，也是肾脏疾病和心血管病理生理学的生物标志物。我们进行了这项横断面观察性研究，以探讨血浆NGAL和胸主动脉钙化（TAC）的维持性血液透析（MHD）患者与糖尿病和非糖尿病之间的关系。采用ELISA法测定血浆NGAL，采用计算机断层扫描三维定量法或胸部X线片主动脉弓钙化评分法评价TAC。采用斯皮尔曼相关分析、Logistic回归分析和偏相关分析等方法对NGAL与TAC进行相关性分析。合并糖尿病的MHD患者的血浆NGAL水平低于无糖尿病的MHD患者（49.33（42.37，55.48）vs 56.78（44.37，674.13）ng/mL，P = 0.026）。在无糖尿病的MHD患者中，lg（NGAL）与ARC值呈正相关经斯皮尔曼相关分析（R = 0.612，P = 0.003）;偏相关分析显示，校正年龄和性别后，lg（NGAL）与ARC值呈正相关（R = 0.550，P = 0.015），校正年龄、性别和CHD（R = 0.565，P = 0.015），校正年龄、性别、CHD和Alb（R = 0.536，P = 0.027），或调整年龄、性别、CHD、Alb和透析器膜（聚砜）（R = 0.590，P = 0.016），但校正年龄、性别、CHD、Alb和Ca后，lg（NGAL）与ARC值的相关性消失。斯皮尔曼相关分析显示NGAL与Ca（R = 0.644，P < 0.001）、Ca与ACR（R = 0.534，P = 0.013）呈正相关。非糖尿病MHD患者血浆NGAL与血清Ca、ARC呈正相关，提示NGAL可能参与了非糖尿病MHD患者心血管钙化的发生。在线版本包含补充材料，可通过10.1186/s12882-022-02773-z获得。
Neutrophil gelatinase-associated lipocalin (NGAL) is not only a bone-derived factor involved in metabolism, but also a biomarker of kidney disease and cardiovascular pathophysiology. We conducted this cross-sectional observational study to explore relationships between plasma NGAL and thoracic aorta calcification (TAC) in maintenance hemodialysis (MHD) patients with and without diabetes. Plasma NGAL was measured by ELISA, TAC was evaluated via computed tomography scan using a 3D quantification method or chest radiography aortic arch calcification score. Spearman correlation, Logistic regression and Partial correlation analysis were used to describe the correlations between NGAL and TAC. Plasma NGAL levels were lower in MHD patients with diabetes compared to those without diabetes (49.33(42.37, 55.48) vs 56.78(44.37, 674.13) ng/mL, P = 0.026). In MHD patients without diabetes, lg (NGAL) was positively correlated with ARC value(R = 0.612, P = 0.003) analyzed by Spearman correlation; for partial correlation analysis, lg (NGAL) was positively correlated with ARC value, after adjusting for age and sex (R = 0.550, P = 0.015), adjusting for age, sex and CHD (R = 0.565, P = 0.015), adjusting for age, sex, CHD and Alb (R = 0.536, P = 0.027), or adjusting for age, sex, CHD, Alb, and dialyzer membrane (polysulfone) (R = 0.590, P = 0.016); however, when adjusting for age, sex, CHD, Alb and Ca, the correlation between lg (NGAL) and ARC value disappeared. Positive correlation were found between NGAL and Ca (R = 0.644, P < 0.001), Ca and ACR (R = 0.534, P = 0.013) in Spearman coefficient analysis. There were positive correlations among plasma NGAL, serum Ca and ARC in MHD patients without diabetes; which suggests that NGAL is possibly a participant in cardiovascular calcification, in non-diabetic MHD. The online version contains supplementary material available at 10.1186/s12882-022-02773-z.
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影响因子：
4.4
作者：
Okada H;Tada H;Hayashi K;Kawashima H;Takata T;Sakata K;Nohara A;Mabuchi H;Yamagishi M;Kawashiri MA
通讯作者：
Kawashiri MA
影响因子：
64.8
作者：
Mosialou I;Shikhel S;Liu JM;Maurizi A;Luo N;He Z;Huang Y;Zong H;Friedman RA;Barasch J;Lanzano P;Deng L;Leibel RL;Rubin M;Nickolas T;Chung W;Zeltser LM;Williams KW;Pessin JE;Kousteni S
通讯作者：
Kousteni S
影响因子：
3.3
作者：
Henaut, Lucie;Chillon, Jean-Marc;Massy, Ziad A.
通讯作者：
Massy, Ziad A.
Lipocalin-2/ngal作为炎症和代谢疾病的生物标志物的潜力。
DOI：
10.3109/1354750x.2015.1123354
发表时间：
2015
期刊：
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
影响因子：
--
作者：
Abella V;Scotece M;Conde J;Gómez R;Lois A;Pino J;Gómez-Reino JJ;Lago F;Mobasheri A;Gualillo O
通讯作者：
Gualillo O
影响因子：
4.6
作者：
Lekva T;Gullestad L;Broch K;Aukrust P;Andreassen AK;Ueland T
通讯作者：
Ueland T