Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer.
Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer.
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DOI：
10.1038/bjc.2013.330
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发表时间：
2013-07-09
影响因子：
8.8
通讯作者：
McMillan DC
中科院分区：
文献类型：
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作者：
Guthrie GJ;Roxburgh CS;Farhan-Alanie OM;Horgan PG;McMillan DC
基于系统性炎症的预后评分、改进的格拉斯哥预后评分（mGPS）和中性粒细胞淋巴细胞比率（NLR）现在被认为可用于预测治疗前各种实体器官恶性肿瘤（包括结直肠癌（CRC））的生存。然而，似乎没有对这些系统性炎症的纵向测量进行直接比较。因此，本研究的目的是比较系统性炎症的纵向测量、mGPS和NLR在接受可能治愈的结直肠癌切除术的患者中的预后价值。2006年至2010年间，326名患者接受了可能治愈的结直肠癌切除术。206例患者术前和术后（3-6个月）均有完整的生化和血液学数据。在206例患者中，从术前到术后，mGPS或NLR没有明显的总体变化。在单因素生存分析中，t分期（P<0.001）、肿瘤、淋巴结、转移分期（P<0.005）、术前mGPS （P<0.05）、术前NLR（<0.05）、术后mGPS （P<0.001）和术后NLR （P<0.005）与肿瘤特异性生存相关。在多因素生存分析中，比较术前mGPS和NLR，术前mGPS和NLR均与肿瘤特异性生存降低独立相关（mGPS风险比（HR） 1.97, CI 1.16-3.34， P<0.05, NLR HR 3.07, CI 1.23-7.63， P<0.05）。当对术后数据进行相同的多变量比较时，只有术后mGPS与癌症特异性生存独立相关（HR 4.81, CI 2.13-10.83， P<0.001）。本研究的结果支持系统性炎症反应的纵向评估，特别是mGPS，在接受可能治愈的结直肠癌切除术的患者中。
The systemic inflammation-based prognostic scores, modified Glasgow Prognostic Score (mGPS) and the neutrophil-lymphocyte ratio (NLR) are now recognised to be useful in predicting survival in a variety of solid organ malignancies, including colorectal cancer (CRC) before treatment. However, there would appear to have been no direct comparison of these longitudinal measurements of systemic inflammation. Therefore, the aim of the present study was to compare the prognostic value of longitudinal measures of systemic inflammation, the mGPS and NLR in patients undergoing potentially curative resection for CRC. Three hundred and twenty-six patients underwent potentially curative resection for CRC between 2006 and 2010. Full biochemical and haematological data both pre- and post-operatively (3–6 months) were available for 206 patients. In 206 patients, there was no significant overall change in either the mGPS or the NLR, from pre- to post-operatively. On univariate survival analysis, T-stage (P<0.001), tumour, node, metastasis stage (P<0.005), pre-operative mGPS (P<0.05), pre-operative NLR (<0.05), post-operative mGPS (P<0.001) and post-operative NLR (P<0.005) were associated with cancer-specific survival. On multivariate survival analysis, comparing pre-operative mGPS and NLR, both pre-operative mGPS and NLR were independently associated with reduced cancer-specific survival (mGPS hazard ratio (HR) 1.97, CI 1.16–3.34, P<0.05, and NLR HR 3.07, CI 1.23–7.63, P<0.05). When the same multivariate comparison was carried out on post-operative data, only the post-operative mGPS was independently associated with cancer-specific survival (HR 4.81, CI 2.13–10.83, P<0.001). The results of the present study support the longitudinal assessment of the systemic inflammatory response, in particular the mGPS, in patients undergoing potentially curative resection for CRC.
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影响因子：
9.6
作者：
LEWI, H;BLUMGART, LH;MCARDLE, CS
通讯作者：
MCARDLE, CS
影响因子：
8.4
作者：
Proctor, Michael J.;Morrison, David S.;McMillan, Donald C.
通讯作者：
McMillan, Donald C.
影响因子：
9.6
作者：
McMillan, DC;Canna, K;McArdle, CS
通讯作者：
McArdle, CS
影响因子：
3.7
作者：
Oliphant, Raymond;Nicholson, Gary A.;Morrison, David S.
通讯作者：
Morrison, David S.
影响因子：
8.8
作者：
通讯作者：
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