Chemical constituents of Aspergillus udagawae isolated from the soil of the Xingren coal areas and their antibacterial activities
Chemical constituents of Aspergillus udagawae isolated from the soil of the Xingren coal areas and their antibacterial activities
复制标题
兴仁煤区土壤中乌达川曲霉的化学成分及其抑菌活性
DOI：
10.1080/14786419.2022.2137798
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发表时间：
2022-10
影响因子：
2.2
通讯作者：
Guo-Bo Xu
中科院分区：
文献类型：
--
作者：
Xing-Mei Long;Qin-Feng Zhu;Bing Wang;Guang-Gui Chen;Kai-Yu Li;Xun He;Shang-Gao Liao;Guo-Bo Xu
摘要利用生物活性导向的分级分离方法，从烟曲霉菌MST 1 -10的代谢产物中分离得到一个新的香草酸衍生物（1）和9个已知化合物（2-10）。通过波谱分析鉴定了化合物的结构。通过NOESY和ECD光谱确定了化合物1的绝对构型。化合物2对嗜麦芽窄食单胞菌具有明显的抗菌活性，其MIC值为2 μg/mL（甲氧苄啶，MIC = 64 μg/mL），在4 MIC、2 MIC和MIC下，生物膜抑制率分别为96.41%、87.77%和41.70%。图形摘要
Abstract A new helvolic acid derivative (1), together with nine known compounds (2-10) were isolated from the metabolites of Aspergillus udagawae MST1-10 with the bioassay-guided fractionation method. Their structures were identified on the basis of spectroscopic analysis. The absolute configuration of compound 1 was elucidated through NOESY and ECD spectra. Compound 2 displayed significant antibacterial activities against Stenotrophomonas maltophilia with MIC value of 2 μg/mL (Trimethoprim, MIC = 64 μg/mL), and with biofilm inhibition rates of 96.41%, 87.77%, and 41.70% at 4MIC, 2MIC, and MIC, respectively. Graphical Abstract
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DOI：
--
发表时间：
2014
期刊：
--
影响因子：
--
作者：
Andrew M. Q. King;Sarah A. Reid-Yu;Wenliang Wang;D. King;G. D. Pascale;N. Strynadka;T. Walsh;
通讯作者：
Andrew M. Q. King;Sarah A. Reid-Yu;Wenliang Wang;D. King;G. D. Pascale;N. Strynadka;T. Walsh;
影响因子：
3.8
作者：
Liu, Xue;Cai, Jiaxin;Chen, Wenxue
通讯作者：
Chen, Wenxue
影响因子：
3.8
作者：
Zhao, Wen-Yu;Yi, Jing;Ma, Xiao-Chi
通讯作者：
Ma, Xiao-Chi
影响因子：
2.2
作者：
Usama W. Hawas;Lamia T Abou El-Kassem;E. Ahmed;Rana A. Alghamdi
通讯作者：
Usama W. Hawas;Lamia T Abou El-Kassem;E. Ahmed;Rana A. Alghamdi
影响因子：
0.8
作者：
Shilei Wang;Hang-Fei Yu;Yi-Lian Xu;Ting Tian;Z. Zhan;W. Shan;Youmin Ying
通讯作者：
Shilei Wang;Hang-Fei Yu;Yi-Lian Xu;Ting Tian;Z. Zhan;W. Shan;Youmin Ying