Post-COVID syndrome. A case series and comprehensive review.
Post-COVID syndrome. A case series and comprehensive review.
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DOI：
10.1016/j.autrev.2021.102947
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发表时间：
2021-11
影响因子：
13.6
通讯作者：
Ramírez-Santana C
中科院分区：
文献类型：
--
作者：
Anaya JM;Rojas M;Salinas ML;Rodríguez Y;Roa G;Lozano M;Rodríguez-Jiménez M;Montoya N;Zapata E;Post-COVID study group;Monsalve DM;Acosta-Ampudia Y;Ramírez-Santana C
持续时间超过COVID-19急性期的各种症状的存在被称为COVID后综合征（PCS）。我们的目的是报告一系列患有PCS的患者在COVID后病房就诊，并就该主题进行全面审查。通过一项半结构化和有效的调查，对先前确诊的SARS-CoV-2感染和PCS的成人患者进行了系统评估。采用电化学发光免疫分析法检测SARS-CoV-2血清总IgG、伊加和IgM抗体。根据PRISMA指南，对文献进行系统回顾和荟萃分析。采用单因素和多因素方法对数据进行分析。在总共100名连续患者中，53名为女性，年龄中位数为49岁（IQR：37.8-55.3），首次出现症状后的COVID后时间中位数为219天（IQR：143-258），65名患者在急性COVID-19期间住院。肌肉骨骼、消化系统（即，腹泻）和神经系统症状包括抑郁（Zung量表）是PCS患者中最常见的。既往住院与PCS表现无关。关节痛和腹泻持续超过40%的PCS患者。抗SARS-CoV-2抗体中位数为866.2 U/mL（IQR：238.2-1681）。尽管存在这种变异性，但98例患者的血清反应呈阳性。基于自主神经症状（COMPASS 31），获得具有不同临床特征的两个聚类。抗SARS-CoV-2抗体水平在集群之间没有差异。荟萃分析共纳入40篇文章（11，196例患者）。超过20%的报告患者出现疲劳/肌无力、呼吸困难、疼痛和不适、焦虑/抑郁和注意力受损。总之，PCS的主要特点是肌肉骨骼，肺，消化系统和神经系统的参与，包括抑郁症。PCS与急性疾病的严重程度和体液反应无关。证实了对SARS-CoV-2感染的长期抗体应答和较高的个体间变异性。未来的研究应评估SARS-CoV-2可能导致PCS的机制和最佳治疗方案。
The existence of a variety of symptoms with a duration beyond the acute phase of COVID-19, is referred to as post-COVID syndrome (PCS). We aimed to report a series of patients with PCS attending a Post-COVID Unit and offer a comprehensive review on the topic. Adult patients with previously confirmed SARS-CoV-2 infection and PCS were systematically assessed through a semi-structured and validated survey. Total IgG, IgA and IgM serum antibodies to SARS-CoV-2 were evaluated by an electrochemiluminescence immunoassay. A systematic review of the literature and meta-analysis were conducted, following PRISMA guidelines. Univariate and multivariate methods were used to analyze data. Out of a total of 100 consecutive patients, 53 were women, the median of age was 49 years (IQR: 37.8–55.3), the median of post-COVID time after the first symptoms was 219 days (IQR: 143–258), and 65 patients were hospitalized during acute COVID-19. Musculoskeletal, digestive (i.e., diarrhea) and neurological symptoms including depression (by Zung scale) were the most frequent observed in PCS patients. A previous hospitalization was not associated with PCS manifestation. Arthralgia and diarrhea persisted in more than 40% of PCS patients. The median of anti-SARS-CoV-2 antibodies was 866.2 U/mL (IQR: 238.2–1681). Despite this variability, 98 patients were seropositive. Based on autonomic symptoms (by COMPASS 31) two clusters were obtained with different clinical characteristics. Levels of anti-SARS-CoV-2 antibodies were not different between clusters. A total of 40 articles (11,196 patients) were included in the meta-analysis. Fatigue/muscle weakness, dyspnea, pain and discomfort, anxiety/depression and impaired concentration were presented in more than 20% of patients reported. In conclusion, PCS is mainly characterized by musculoskeletal, pulmonary, digestive and neurological involvement including depression. PCS is independent of severity of acute illness and humoral response. Long-term antibody responses to SARS-CoV-2 infection and a high inter-individual variability were confirmed. Future studies should evaluate the mechanisms by which SARS-CoV-2 may cause PCS and the best therapeutic options.
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DOI：
10.1016/j.cmi.2021.02.014
发表时间：
2021-06
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Folgueira MD;Luczkowiak J;Lasala F;Pérez-Rivilla A;Delgado R
通讯作者：
Delgado R
DOI：
10.1016/j.jcjo.2020.12.008
发表时间：
2021-04
期刊：
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
影响因子：
--
作者：
Arjmand P;Murtaza F;Eshtiaghi A;Popovic MM;Kertes PJ;Eng KT
通讯作者：
Eng KT
影响因子：
20.3
作者：
Giannis D;Allen SL;Tsang J;Flint S;Pinhasov T;Williams S;Tan G;Thakur R;Leung C;Snyder M;Bhatia C;Garrett D;Cotte C;Isaacs S;Gugerty E;Davidson A;Marder GS;Schnitzer A;Goldberg B;McGinn T;Davidson KW;Barish MA;Qiu M;Zhang M;Goldin M;Matsagkas M;Arnaoutoglou E;Spyropoulos AC
通讯作者：
Spyropoulos AC
影响因子：
2.6
作者：
Blitshteyn, S.
通讯作者：
Blitshteyn, S.
影响因子：
7.4
作者：
Fernandez-de-las-Penas, Cesar;Rodriguez-Jimenez, Jorge;Arendt-Nielsen, Lars
通讯作者：
Arendt-Nielsen, Lars