Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST).
Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST).
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DOI：
10.1186/s12874-017-0402-9
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发表时间：
2017-09-07
影响因子：
4
通讯作者：
Bonfill X
中科院分区：
文献类型：
--
作者：
Ballesteros M;Montero N;López-Pousa A;Urrútia G;Solà I;Rada G;Pardo-Hernandez H;Bonfill X
胃肠道间质肿瘤（GIST）是最常见的间质肿瘤。目前，不同的药物和手术方案被用于治疗局部和转移性胃肠道间质瘤，尽管这一研究领域很广泛，而且证据体系分散且不断扩大。我们的目标是通过证据映射方法来识别、描述和组织当前可用的 GIST 证据。我们遵循全球证据图（GEM）的方法。我们检索了 Pubmed、EMBASE、Cochrane 图书馆和 Epistemonikos，以确定 1990 年至 2016 年 3 月期间发表或未发表荟萃分析的系统评价 (SR)。两位作者评估了资格并提取了数据。使用 AMSTAR 评估纳入的系统评价的方法学质量。我们根据确定的 PICO 问题组织结果，并以表格和气泡图形式呈现证据图。共有 17 名 SR 符合资格标准。这些审查包括 66 项单独研究，其中四分之三是观察性或非对照临床试验。总体而言，所包含的 SR 的质量为中等或较高。我们总共从他们中提取了 14 个 PICO 问题，相应的结果大多有利于干预组。用于评估 GIST 肉瘤治疗干预的最常见研究类型是非实验研究。然而，大多数干预措施均被 SR 的各自作者报告为有益或可能有益。证据映射是一种有用且可靠的方法，用于识别和呈现有关治疗干预的现有证据。本文的在线版本 (doi:10.1186/s12874-017-0402-9) 包含补充材料，可供授权用户使用。
Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. We followed the methodology of Global Evidence Mapping (GEM). We searched Pubmed, EMBASE, The Cochrane Library and Epistemonikos in order to identify systematic reviews (SRs) with or without meta-analyses published between 1990 and March 2016. Two authors assessed eligibility and extracted data. Methodological quality of the included systematic reviews was assessed using AMSTAR. We organised the results according to identified PICO questions and presented the evidence map in tables and a bubble plot. A total of 17 SRs met eligibility criteria. These reviews included 66 individual studies, of which three quarters were either observational or uncontrolled clinical trials. Overall, the quality of the included SRs was moderate or high. In total, we extracted 14 PICO questions from them and the corresponding results mostly favoured the intervention arm. The most common type of study used to evaluate therapeutic interventions in GIST sarcomas has been non-experimental studies. However, the majority of the interventions are reported as beneficial or probably beneficial by the respective authors of SRs. The evidence mapping is a useful and reliable methodology to identify and present the existing evidence about therapeutic interventions. The online version of this article (doi:10.1186/s12874-017-0402-9) contains supplementary material, which is available to authorized users.
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亚洲共识指南，以诊断和管理胃肠道基质肿瘤。
影响因子：
4.6
作者：
Koo DH;Ryu MH;Kim KM;Yang HK;Sawaki A;Hirota S;Zheng J;Zhang B;Tzen CY;Yeh CN;Nishida T;Shen L;Chen LT;Kang YK
通讯作者：
Kang YK
腹腔镜胃肠道胃肠道肿瘤的腹腔镜与开放切除：一项更新的系统审查和荟萃分析。
影响因子：
3.2
作者：
Chen QL;Pan Y;Cai JQ;Wu D;Chen K;Mou YP
通讯作者：
Mou YP
影响因子：
7.2
作者：
Guyatt, Gordon H.;Oxman, Andrew D.;Knottnerus, Andre
通讯作者：
Knottnerus, Andre
影响因子：
7.2
作者：
Clavisi, Ornella;Bragge, Peter;Gruen, Russell L.
通讯作者：
Gruen, Russell L.
影响因子：
3.8
作者：
Starczewska Amelio JM;Cid Ruzafa J;Desai K;Tzivelekis S;Muston D;Khalid JM;Ashman P;Maguire A
通讯作者：
Maguire A