Requirement for commissureless2 function during dipteran insect nerve cord development.
Requirement for commissureless2 function during dipteran insect nerve cord development.
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DOI：
10.1002/dvdy.24059
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发表时间：
2013-12
影响因子：
2.5
通讯作者：
Duman-Scheel, Molly
中科院分区：
文献类型：
--
作者：
Sarro, Joseph;Andrews, Emily;Sun, Longhua;Behura, Susanta K.;Tan, John C.;Zeng, Erliang;Severson, David W.;Duman-Scheel, Molly
关键词：
在黑腹果蝇中，无连合（commissureless，简称commissureless）功能是正常神经索发育所必需的。虽然在果蝇属物种之外还没有鉴定出comm2的直系同源物，但一些昆虫具有果蝇comm2的直系同源物，其也可以调节胚胎神经索的发育。在这里，这一假设是探讨通过两种疾病媒介蚊子的comm2基因的特性。致倦库蚊（西尼罗和淋巴丝虫病载体）有三个comm2基因在发育中的神经索中表达。埃及伊蚊（登革热和黄热病媒介）有一个单一的comm2基因，表达在连合神经元向中线投射轴突。两个A中的comm2功能丧失。aegypti和D.发现黑腹果蝇导致合缝缺陷的丧失，该合缝缺陷的表型复制了在两个物种中观察到的功能表型的疲劳（FRA）丧失。在任一种昆虫中发现fra功能的丧失导致在神经索发育期间comm2转录水平降低。本研究结果表明，Fra通过调节A. aegypti和D.黑腹肌，两者都需要Comm2功能来进行适当的神经索发育，
In Drosophila melanogaster, commissureless (comm) function is required for proper nerve cord development. Although comm orthologs have not been identified outside of Drosophila species, some insects possess orthologs of Drosophila comm2, which may also regulate embryonic nerve cord development. Here, this hypothesis is explored through characterization of comm2 genes in two disease vector mosquitoes. Culex quinquefasciatus (West Nile and lymphatic filiariasis vector) has three comm2 genes that are expressed in the developing nerve cord. Aedes aegypti (dengue and yellow fever vector) has a single comm2 gene that is expressed in commissural neurons projecting axons toward the midline. Loss of comm2 function in both A. aegypti and D. melanogaster was found to result in loss of commissure defects that phenocopy the frazzled (fra) loss of function phenotypes observed in both species. Loss of fra function in either insect was found to result in decreased comm2 transcript levels during nerve cord development. The results of this investigation suggest that Fra downregulates repulsion in precrossing commissural axons by regulating comm2 levels in both A. aegypti and D. melanogaster, both of which require Comm2 function for proper nerve cord development,
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影响因子：
3.7
作者：
Behura SK;Haugen M;Flannery E;Sarro J;Tessier CR;Severson DW;Duman-Scheel M
通讯作者：
Duman-Scheel M
影响因子：
3
作者：
Flannery, Ellen;VanZomeren-Dohm, Adrienne;Duman-Scheel, Molly
通讯作者：
Duman-Scheel, Molly
影响因子：
12.3
作者：
Cook RK;Christensen SJ;Deal JA;Coburn RA;Deal ME;Gresens JM;Kaufman TC;Cook KR
通讯作者：
Cook KR
影响因子：
1.6
作者：
LEONTOVICH, AM;BRODSKY, LI;GORBALENYA, AE
通讯作者：
GORBALENYA, AE
影响因子：
25
作者：
Keleman, K;Ribeiro, C;Dickson, BJ
通讯作者：
Dickson, BJ