Behavior modulates effective connectivity between cortex and striatum.
Behavior modulates effective connectivity between cortex and striatum.
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DOI：
10.1371/journal.pone.0089443
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Beggs JM
中科院分区：
文献类型：
--
作者：
Nakhnikian A;Rebec GV;Grasse LM;Dwiel LL;Shimono M;Beggs JM
众所周知，要理解基底神经节中的相互作用是非常困难的，因为有多个循环回路。另一个复杂之处是，那里的活动强烈依赖于行为，这表明定向交互或有效连接可以动态变化。一个简单的方法是只检查从皮层到纹状体的直接单突触投射，并将其与从纹状体到皮层的多突触反馈连接进行对比。其他人先前对这一通路的有效连接的研究表明，皮质的活动可以用来预测纹状体的活动，但纹状体的活动不能预测皮质的活动。然而，这项工作是在麻醉或捕获的动物中进行的，因此不可能知道自由行为如何影响有效的连接。为了解决这个问题，我们应用格兰杰因果关系的局部场电位信号在自由行为的大鼠皮层和纹状体。与以前的结果一致，我们发现，在麻醉和静息状态下，从皮层到纹状体的有效连接在很大程度上是单向的。有趣的是，我们发现，在自由行为期间，有效连接变得双向。这些结果是我们所知的第一个表明纹状体对皮质的影响可以像皮质对纹状体的影响一样强烈。此外，这些发现强调了行为状态如何影响基底神经节的相互作用。最后，我们认为，这种方法可能是有用的帕金森氏症或亨廷顿氏病的研究，其中有效的连接可能会改变运动。
It has been notoriously difficult to understand interactions in the basal ganglia because of multiple recurrent loops. Another complication is that activity there is strongly dependent on behavior, suggesting that directional interactions, or effective connections, can dynamically change. A simplifying approach would be to examine just the direct, monosynaptic projections from cortex to striatum and contrast this with the polysynaptic feedback connections from striatum to cortex. Previous work by others on effective connectivity in this pathway indicated that activity in cortex could be used to predict activity in striatum, but that striatal activity could not predict cortical activity. However, this work was conducted in anesthetized or seizing animals, making it impossible to know how free behavior might influence effective connectivity. To address this issue, we applied Granger causality to local field potential signals from cortex and striatum in freely behaving rats. Consistent with previous results, we found that effective connectivity was largely unidirectional, from cortex to striatum, during anesthetized and resting states. Interestingly, we found that effective connectivity became bidirectional during free behaviors. These results are the first to our knowledge to show that striatal influence on cortex can be as strong as cortical influence on striatum. In addition, these findings highlight how behavioral states can affect basal ganglia interactions. Finally, we suggest that this approach may be useful for studies of Parkinson's or Huntington's diseases, in which effective connectivity may change during movement.
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影响因子：
2.9
作者：
Dorner JL;Miller BR;Klein EL;Murphy-Nakhnikian A;Andrews RL;Barton SJ;Rebec GV
通讯作者：
Rebec GV
DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
3.5
作者：
Berke, Joshua D.;Hetrick, Vaughn;Greene, Robert W.
通讯作者：
Greene, Robert W.
影响因子：
3.7
作者：
GEWEKE, JF
通讯作者：
GEWEKE, JF
影响因子：
3.7
作者：
Barrett AB;Murphy M;Bruno MA;Noirhomme Q;Boly M;Laureys S;Seth AK
通讯作者：
Seth AK