Influence of ketamine on amino acid neurotransmitters secretion by nerve cells in vitro
Influence of ketamine on amino acid neurotransmitters secretion by nerve cells in vitro
复制标题
氯胺酮对体外神经细胞分泌氨基酸神经递质的影响
DOI：
10.3329/bjp.v11is1.26411
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
高利
中科院分区：
文献类型：
--
作者：
师铭咸;陈蕊;郭岑;高利
为了研究氯胺酮治疗后神经细胞分泌的氨基酸神经递质的影响，在体外培养神经细胞，以排除其他因子在体内的干扰，并用三种不同剂量的KET治疗
In order to study the influence of amino acid neurotransmitters secreted by the nerve cells after ketamine treatment, the nerve cells were cultured in vitro to exclude the interference of other factors in vivo and treated with three different doses of ketamine (1, 3 and 5 µg/mL). Then, the concentration of neuronal amino acid neurotransmitters was examined at 0, 15, 30, 45, 60, 90, 120 min after treatment. The trends of each amino acid concentration after ketamine treatment were nearly the same among the different treatment doses. After 15 min of adapting time, ketamine decreased the excitatory amino acid glutamic acid and aspartic acid concentration, and increased the concentration of the inhibitory amino acid glycine. Their concentrations showed a tendency to return approximately to the original level after 120 min.
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影响因子：
14.8
作者：
Beaudoin, Gerard M. J., III;Lee, Seung-Hye;Arikkath, Jyothi
通讯作者：
Arikkath, Jyothi
DOI：
10.1016/b978-012373898-1.50014-0
发表时间：
2008-01-01
期刊：
ANESTHESIA AND ANALGESIA IN LABORATORY ANIMALS, 2ND EDITION
影响因子：
--
作者：
Gaertner, Diane J.;Hallman, Troy M.;Batchelder, Margaret A.
通讯作者：
Batchelder, Margaret A.
影响因子：
2.5
作者：
Mak, Ying T.;Lam, Wai P.;Yew, David T.
通讯作者：
Yew, David T.
影响因子：
4.5
作者：
Boveris, AD;Puntarulo, S
通讯作者：
Puntarulo, S
影响因子：
8.8
作者：
Miyazaki, H;Nakamura, Y;Kataoka, K
通讯作者：
Kataoka, K