Sex on the Brain: Reproductive Comorbidities in Temporal Lobe Epilepsy.
Sex on the Brain: Reproductive Comorbidities in Temporal Lobe Epilepsy.
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DOI：
10.1177/15357597221135717
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发表时间：
2023-01
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
张建军，张建军，李建军，等。海马内注射Kainic酸后GABA向GnRH神经元传递的性别特异性研究[J] .中华神经科学杂志，2013;32(2):562 - 562。癫痫患者出现生殖内分泌合并症的比例高于一般人群。临床研究发现，在两性患者中，黄体生成素（LH）释放模式被破坏，这表明下丘脑促性腺激素释放激素（GnRH）神经元功能可能发生与癫痫相关的变化。在之前的工作中，我们发现在海马内kainic酸（IHKA）小鼠颞叶癫痫模型中，雌性和雄性的GnRH神经元放电增加。值得注意的是，GABAA受体激活在成人GnRH神经元中是去极化的。因此，我们在这里验证了IHKA小鼠GnRH神经元放电增加与GnRH神经元gaba能驱动增加相关的假设。当阻断嗜离子性谷氨酸受体（iGluRs）以分离gaba能突触后电流（PSCs）时，对照组和IHKA发情雌性GnRH神经元的PSC频率没有差异。然而，在没有iGluR阻断的情况下，来自月经周期中断的IHKA雌性小鼠的GnRH神经元中GABA PSC频率增加，但没有盐水注射对照组和没有月经周期中断的IHKA雌性小鼠。发情周期中断的IHKA雌性GABA PSC振幅也增加。这些发现表明，存在iglur依赖性的前馈gaba能传递到GnRH神经元的增加，这是IHKA女性共病周期中断所特有的。在雄性中，GABA的PSC频率和振幅不变，但PSC持续时间缩短。综上所述，这些研究结果表明，GABA传递的增加有助于IHKA雌性小鼠在发情时放电升高，并表明在IHKA小鼠生殖内分泌功能障碍中存在一种性别特异性的下丘脑机制。
Increased GABA Transmission to GnRH Neurons After Intrahippocampal Kainic Acid Injection in Mice Is Sex-Specific and Associated With Estrous Cycle Disruption Ingram RJ, Leverton LK, Daniels VC, Li J, Christian-Hinman CA. Neurobiol Dis. 2022;172:105822. doi:10.1016/j.nbd.2022.105822 Patients with epilepsy develop reproductive endocrine comorbidities at a rate higher than that of the general population. Clinical studies have identified disrupted luteinizing hormone (LH) release patterns in patients of both sexes, suggesting potential epilepsy-associated changes in hypothalamic gonadotropin-releasing hormone (GnRH) neuron function. In previous work, we found that GnRH neuron firing is increased in diestrous females and males in the intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy. Notably, GABAA receptor activation is depolarizing in adult GnRH neurons. Therefore, here we tested the hypothesis that increased GnRH neuron firing in IHKA mice is associated with increased GABAergic drive to GnRH neurons. When ionotropic glutamate receptors (iGluRs) were blocked to isolate GABAergic postsynaptic currents (PSCs), no differences in PSC frequency were seen between GnRH neurons from control and IHKA diestrous females. In the absence of iGluR blockade, however, GABA PSC frequency was increased in GnRH neurons from IHKA females with disrupted estrous cycles, but not saline-injected controls nor IHKA females without estrous cycle disruption. GABA PSC amplitude was also increased in IHKA females with disrupted estrous cycles. These findings suggest the presence of an iGluR-dependent increase in feed-forward GABAergic transmission to GnRH neurons specific to IHKA females with comorbid cycle disruption. In males, GABA PSC frequency and amplitude were unchanged but PSC duration was reduced. Together, these findings suggest that increased GABA transmission helps drive elevated firing in IHKA females on diestrus and indicate the presence of a sex-specific hypothalamic mechanism underlying reproductive endocrine dysfunction in IHKA mice.
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影响因子：
3.3
作者：
Font, Sarah;Maguire-Jack, Kathryn
通讯作者：
Maguire-Jack, Kathryn
影响因子：
3
作者：
Herzog, Andrew G.
通讯作者：
Herzog, Andrew G.
DOI：
10.1080/1067828x.2012.735514
发表时间：
2014-01-01
影响因子：
0.6
作者：
Casanueva, Cecilia;Stambaugh, Leyla;Williams, Jason
通讯作者：
Williams, Jason
影响因子：
6.1
作者：
Ingram, Robbie J.;Leverton, Leanna K.;Daniels, Victoria C.;Li, Jiang;Christian-Hinman, CatherineA.
通讯作者：
Christian-Hinman, CatherineA.
影响因子：
3.3
作者：
Cheng, Tyrone C.;Lo, Celia C.
通讯作者：
Lo, Celia C.