Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity.

Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity.
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DOI:
10.1111/sms.14205
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发表时间:
2022-09
影响因子:
4.1
通讯作者:
Kaprio, Jaakko
Kaprio, Jaakko
中科院分区:
医学2区
文献类型:
--
作者:
Kujala, Urho M.;Leskinen, Tuija;Rottensteiner, Mirva;Aaltonen, Sari;Ala-Korpela, Mika;Waller, Katja;Kaprio, Jaakko

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遗传和早期环境差异,包括早期健康习惯,与未来的健康有关。为了深入了解这些关联的因果性质,健康习惯不一致的同卵(MZ)双胞胎提供了一个有趣的自然实验。因此,成年早期休闲时间体力活动(LTPA)不一致的双胞胎对是一个强有力的研究设计,以调查长期LTPA与健康和幸福指标之间的关联。我们已经确定了17 LTPA不和谐的双胞胎对从两个芬兰双胞胎队列,并总结了这些研究的主要结果在本文中。仔细表征罕见的长期LTPA不一致MZ双胞胎对参加了多维临床检查。关键研究结果强调,与这种MZ双胞胎对中活动较少的双胞胎相比,具有较高长期LTPA的双胞胎具有较高的身体健康,减少体脂,减少内脏脂肪,减少肝脏脂肪,增加下肢导管动脉的管腔直径,增加骨负荷区域的骨矿物质密度,以及增加大的高密度脂蛋白颗粒的数量。这些发现增加了我们对长期LTPA可能的特定地点和系统水平影响的理解。
Genetic and early environmental differences including early health habits associate with future health. To provide insight on the causal nature of these associations, monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure‐time physical activity (LTPA) in early adult life is thus a powerful study design to investigate the associations between long‐term LTPA and indicators of health and wellbeing. We have identified 17 LTPA discordant twin pairs from two Finnish twin cohorts and summarize key findings of these studies in this paper. The carefully characterized rare long‐term LTPA discordant MZ twin pairs have participated in multi‐dimensional clinical examinations. Key findings highlight that compared with less active twins in such MZ twin pairs, the twins with higher long‐term LTPA have higher physical fitness, reduced body fat, reduced visceral fat, reduced liver fat, increased lumen diameters of conduit arteries to the lower limbs, increased bone mineral density in loaded bone areas, and an increased number of large high‐density lipoprotein particles. The findings increase our understanding on the possible site‐specific and system‐level effects of long‐term LTPA.
对体育活动参与的独特环境影响:一项双胞胎研究。
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