Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill.
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill.
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DOI：
10.1038/nn.2261
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发表时间：
2009-03
影响因子：
25
通讯作者：
Costa, Rui M.
中科院分区：
文献类型：
--
作者：
Yin, Henry H.;Mulcare, Shweta Prasad;Hilario, Monica R. F.;Clouse, Emily;Holloway, Terrell;Davis, Margaret I.;Hansson, Anita C.;Lovinger, David M.;Costa, Rui M.
新技能学习的特点是：初始阶段是绩效快速提高的阶段，以及随着技能自动化和绩效渐近线而逐渐改善的阶段。利用体内纹状体记录，我们观察到在技能学习的不同阶段神经活动的区域特异性变化，联想或背内侧纹状体在训练早期优先参与，而感觉运动或背外侧纹状体在训练后期优先参与。对受过训练的小鼠脑切片中的中型多刺纹状体神经元的离体记录表明，体内观察到的变化与纹状体中兴奋性突触传递的区域和训练特异性变化相对应。此外，经过大量训练后，在背外侧纹状体中观察到的谷氨酸能传递增强优先在纹状体苍白球神经元中表达，而不是在纹状体黑质神经元中表达。这些发现表明，当技能变得自动化时，区域和途径特定的可塑性会塑造参与技能表现的回路。
The learning of new skills is characterized by an initial phase of rapid improvement in performance and a phase of more gradual improvements as skills are automatized and performance asymptotes. Using in vivo striatal recordings, we observed region-specific changes in neural activity during the different phases of skill learning, with the associative or dorsomedial striatum being preferentially engaged early in training and the sensorimotor or dorsolateral striatum being engaged later in training. Ex vivo recordings from medium spiny striatal neurons in brain slices of trained mice revealed that the changes observed in vivo corresponded to regional- and training-specific changes in excitatory synaptic transmission in the striatum. Furthermore, the potentiation of glutamatergic transmission observed in dorsolateral striatum after extensive training was preferentially expressed in striatopallidal neurons, rather than striatonigral neurons. These findings demonstrate that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized.
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影响因子：
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通讯作者：
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影响因子：
3.5
作者：
Hilario, Monica R F;Clouse, Emily;Yin, Henry H;Costa, Rui M
通讯作者：
Costa, Rui M