Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study.
Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study.
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国家出生缺陷预防研究中的饮用水消毒副产物和口面部裂风险。
DOI：
10.1002/bdr2.1348
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发表时间：
2018
影响因子：
2.1
通讯作者：
Rom
中科院分区：
文献类型：
--
作者：
Weyer,Peter;Rhoads,Anthony;Suhl,Jonathan;Luben,ThomasJ;Conway,KristinM;Langlois,PeterH;Shen,Dereck;Liang,Dong;Puzhankara,Soman;Anderka,Marlene;Bell,Erin;Feldkamp,MarciaL;Hoyt,AdrienneT;Mosley,Bridget;Reefhuis,Jennita;Rom
背景：母亲接触饮用水消毒副产物（DBP）可能导致口面裂（OFC）的发展，但研究很少且存在局限性。方法以人口为基础，对680例OFC病例（535例隔离病例）和1826例对照者的饮用水过滤和消费情况的产妇访谈报告与使用产妇住址和公共供水系统监测数据的DBP浓度数据进行关联。母亲个体水平暴露于三卤甲烷（THM）和卤乙酸（HAA）s（所消耗的水微克/升）是根据报告的家庭、工作场所和学校的消费量估计的。与没有接触相比，使用logistic回归分析，估计所有OFCs和孤立OFCs、腭裂（CP）和唇裂±腭裂（CL/P）的多源母体接触<总THMs （TTHM）和HAAs （HAA5）的最大污染物水平（MCL）s的1/2或≥1/2与个体THMs和HAAs的最大污染物水平目标（MCLG）s（如果非零）的关联。结果与对照组相比，母体TTHM、HAA5和个体THM暴露与所有OFCs和分离OFCs、CP和CL/P的相关性接近或低于统一。个体HAAs的相关性也接近或低于1，具有统计学意义，除CL/P外，每个OFC结果组均观察到负相关。结论：本研究考察了母亲报告的饮用水过滤和消耗以及母亲从饮用水中暴露DBP与后代OFCs的关系。观察到的关联接近或低于统一，大多数不显著。继续，使用母亲个体水平暴露数据的改进研究将有助于更好地表征这些关联。
BackgroundMaternal exposure to drinking water disinfection byproducts (DBP)s may contribute to orofacial cleft (OFC) development, but studies are sparse and beset with limitations.MethodsPopulation‐based, maternal interview reports of drinking water filtration and consumption for 680 OFC cases (535 isolated) and 1826 controls were linked with DBP concentration data using maternal residential addresses and public water system monitoring data. Maternal individual‐level exposures to trihalomethanes (THM)s and haloacetic acids (HAA)s (µg/L of water consumed) were estimated from reported consumption at home, work, and school. Compared to no exposure, associations with multisource maternal exposure <1/2 or ≥1/2 the Maximum Contaminant Levels (MCL)s for total THMs (TTHM)s and HAAs (HAA5) or Maximum Contaminant Level Goals (MCLG)s for individual THMs and HAAs (if non‐zero) were estimated for all OFCs and isolated OFCs, cleft palate (CP), and cleft lip ± cleft palate (CL/P) using logistic regression analyses.ResultsCompared to controls, associations were near or below unity for maternal TTHM, HAA5, and individual THM exposures with all OFCs and isolated OFCs, CP, and CL/P. Associations also were near or below unity for individual HAAs with statistically significant, inverse associations observed with each OFC outcome group except CL/P.ConclusionsThis study examined associations for maternal reports of drinking water filtration and consumption and maternal DBP exposure from drinking water with OFCs in offspring. Associations observed were near or below unity and mostly nonsignificant. Continued, improved research using maternal individual‐level exposure data will be useful in better characterizing these associations.
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影响因子：
10.4
作者：
Nieuwenhuijsen MJ;Toledano MB;Bennett J;Best N;Hambly P;de Hoogh C;Wellesley D;Boyd PA;Abramsky L;Dattani N;Fawell J;Briggs D;Jarup L;Elliott P
通讯作者：
Elliott P
总三卤甲烷暴露和自然流产流行病学研究中暴露评估方法对风险估计的影响
DOI：
--
发表时间：
2001
期刊：
Journal of Exposure Analysis and Environmental Epidemiology
影响因子：
--
作者：
K. Waller;S. Swan;G. Windham;L. Fenster
通讯作者：
L. Fenster
影响因子：
5
作者：
BOVE, FJ;FULCOMER, MC;SAVRIN, JE
通讯作者：
SAVRIN, JE
影响因子：
5.4
作者：
Brenner, H;Berg, G;Boeing, H
通讯作者：
Boeing, H
饮用水中的氯化消毒副产物和先天性异常：回顾和荟萃分析。
影响因子：
10.4
作者：
Nieuwenhuijsen, Mark J.;Martinez, David;Grellier, James;Bennett, James;Best, Nicky;Iszatt, Nina;Vrijheid, Martine;Toledano, Mireille B.
通讯作者：
Toledano, Mireille B.