Current status of Clostridium difficile infection epidemiology.
Current status of Clostridium difficile infection epidemiology.
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DOI：
10.1093/cid/cis319
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
McDonald LC
中科院分区：
文献类型：
--
作者：
Lessa FC;Gould CV;McDonald LC
近年来，艰难梭菌感染 (CDI) 的流行病学发生了巨大变化，一些国家的发病率和严重程度有所增加，使 CDI 成为全球公共卫生挑战。 CDI 发病率的增加很大程度上归因于一种以前罕见且毒性更强的菌株 BI/NAP1/027 的出现。毒素产量的增加和对氟喹诺酮类药物的高度耐药性使该菌株成为医疗机构中非常成功的病原体。此外，以前被认为处于低风险的人群现在被确定为患有严重的 CDI。最近的遗传分析表明，艰难梭菌具有高度流动的基因组，具有多种机制来修改其内容和功能，这可以使艰难梭菌适应环境变化，并可能导致毒性更强的菌株的出现。面对 CDI 流行病学和微生物学的这些变化，监测系统对于监测趋势并为公共卫生行动提供信息是必要的。
The dramatic changes in the epidemiology of Clostridium difficile infection (CDI) during recent years, with increases in incidence and severity of disease in several countries, have made CDI a global public health challenge. Increases in CDI incidence have been largely attributed to the emergence of a previously rare and more virulent strain, BI/NAP1/027. Increased toxin production and high-level resistance to fluoroquinolones have made this strain a very successful pathogen in healthcare settings. In addition, populations previously thought to be at low risk are now being identified as having severe CDI. Recent genetic analysis suggests that C. difficile has a highly fluid genome with multiple mechanisms to modify its content and functionality, which can make C. difficile adaptable to environmental changes and potentially lead to the emergence of more virulent strains. In the face of these changes in the epidemiology and microbiology of CDI, surveillance systems are necessary to monitor trends and inform public health actions.
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影响因子：
158.5
作者：
McDonald, LC;Killgore, GE;Gerding, DN
通讯作者：
Gerding, DN
影响因子：
4.5
作者：
Kuntz, Jennifer L.;Yang, Ming;Polgreen, Philip M.
通讯作者：
Polgreen, Philip M.
影响因子：
11.8
作者：
McDonald, LC;Owings, M;Jernigan, DB
通讯作者：
Jernigan, DB
影响因子：
4.5
作者：
McDonald, L. Clifford;Coignard, Bruno;Kutty, Preeta K.
通讯作者：
Kutty, Preeta K.
DOI：
10.1056/nejmra0707500
发表时间：
2008-10-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kelly, Ciaran P;LaMont, J Thomas
通讯作者：
LaMont, J Thomas