Interferon-α Treatment for Growing Teratoma Syndrome of the Testis.
Interferon-α Treatment for Growing Teratoma Syndrome of the Testis.
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DOI：
10.1159/000350897
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Horie S
中科院分区：
文献类型：
--
作者：
Inoue M;Hisasue S;Nagae M;China T;Saito K;Isotani S;Yamaguchi R;Ide H;Muto S;Horie S
一名23岁男性，因右侧阴囊肿块及背部疼痛，接受睾丸癌右侧根治性睾丸切除术后接受进一步治疗。患者的CT扫描显示广泛转移到腹膜后淋巴结，未累及肺部。术前α-胎蛋白和人绒毛膜促性腺激素升高（分别为384 ng/ml和112 mIU/ml）。组织病理检查证实为混合性生殖细胞瘤（95%为未成熟畸胎瘤，5%为胚胎癌）。我们开始用博来霉素、依托泊苷和顺铂（BEP）进行化疗。单疗程后，肿瘤标志物开始恢复正常，但放射学证据显示腹膜后肿块继续生长，肺部出现新的转移灶。患者给予依托泊苷、异环磷酰胺、顺铂（VIP）补救性化疗2个疗程。然而，肿块和肺转移继续进展，患者生长迅速，无法耐受治疗的副作用（即恶心、食欲不振和全血细胞减少症）。在与患者及其家属充分讨论后，我们决定开始对患者进行干扰素-α治疗。经本机构伦理委员会批准，天然非重组IFN-α (OIF, Otsuka, Japan) 500万IU，每周两次给药。患者的反应中等，肿瘤生长明显减慢，肺转移稳定。在IFN-α治疗16个月后，他活得很好。
A 23-year-old man with a right scrotal mass and back pain was referred for further treatment after right radical orchiectomy for testicular cancer. CT scans brought by the patient showed extensive metastasis to the retroperitoneal lymph nodes with no lung involvement. α-Fetoprotein and human chorionic gonadotropin were elevated preoperatively (384 ng/ml and 112 mIU/ml, respectively). Confirmation of the histopathologic examination revealed a mixed germ cell tumor (95% immature teratoma and 5% embryonal carcinoma). We started the patient on chemotherapy with bleomycin, etoposide, and cisplatin (BEP). After a single course, tumor markers began to normalize, but there was radiologic evidence of continued growth of the retroperitoneal mass and new metastases in the lung. The patient was given 2 courses of salvage chemotherapy with etoposide, ifosfamide, and cisplatin (VIP). However, the mass and lung metastases continued to progress, and the patient was growing rapidly intolerant of the side effects of treatment (i.e., nausea, appetite loss, and pancytopenia). After thorough discussion with the patient and his family, we decided to start the patient on interferon (IFN)-α therapy. Natural, nonrecombinant IFN-α (OIF, Otsuka, Japan) 5,000,000 IU was administered twice weekly with approval of the ethics committee of our institution. The patient responded moderately with marked deceleration of tumor growth and stabilization of the lung metastases. He is alive and well at 16 months on IFN-α therapy.
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影响因子：
8.4
作者：
André, F;Fizazi, K;Théodore, C
通讯作者：
Théodore, C
DOI：
10.1111/j.1464-410x.1991.tb15109.x
发表时间：
1991-02-01
期刊：
BRITISH JOURNAL OF UROLOGY
影响因子：
--
作者：
JEFFERY, GM;THEAKER, JM;MEAD, GM
通讯作者：
MEAD, GM
分化但没有变性畸胎瘤对干扰素的反应。
影响因子：
8.8
作者：
Rustin, G J;Kaye, S B;Williams, C J;Newlands, E S;Bagshawe, K D;Toy, J L
通讯作者：
Toy, J L
影响因子：
6.2
作者：
LOGOTHETIS, CJ;SAMUELS, ML;JOHNSON, DE
通讯作者：
JOHNSON, DE