Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?
Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?
复制标题
儿童自闭症诊断年龄或症状严重程度是否会因是否使用辅助生殖技术怀孕而有所不同？
DOI：
10.1007/s10803-015-2462-1
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发表时间：
2015
影响因子：
3.9
通讯作者：
Bearman,Peter
中科院分区：
文献类型：
--
作者：
Schieve,LauraA;Fountain,Christine;Boulet,ShereeL;Yeargin-Allsopp,Marshalyn;Kissin,DmitryM;Jamieson,DeniseJ;Rice,Catherine;Bearman,Peter
先前的研究报告了辅助生殖技术（ART）和自闭症之间的关系。这些关联是否反映了一种确定或生物学效应尚不确定。我们评估了来自加州发展服务部记录、出生记录和国家ART监测系统的连锁研究的> 30，000名自闭症儿童的诊断年龄和初始自闭症症状严重程度。ART妊娠儿童的中位诊断年龄和症状严重程度显著低于非ART妊娠儿童。在对两组的社会人口学特征差异进行调整后，诊断年龄差异大大减弱，自闭症诊断没有差异。因此，与SES相关的确定问题，而不是ART本身，可能是我们最初观察到的差异的驱动力。
Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among >30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART-conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagnosis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascertainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed.
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影响因子：
3.9
作者：
Croen, LA;Grether, JK;Selvin, S
通讯作者：
Selvin, S
辅助生殖技术治疗后的多胎妊娠：人口趋势和未来方向
DOI：
10.2217/17455057.3.3.301
发表时间：
2007
期刊：
Women's Health
影响因子：
--
作者：
L. Schieve
通讯作者：
L. Schieve
DOI：
--
发表时间：
2014-03
期刊：
Morbidity and mortality weekly report. Surveillance summaries
影响因子：
--
作者：
J. Baio
通讯作者：
J. Baio
影响因子：
5
作者：
Schieve, Laura A.;Devine, Owen;Warner, Lee
通讯作者：
Warner, Lee
影响因子：
12.7
作者：
Fountain, Christine;Zhang, Yujia;Bearman, Peter
通讯作者：
Bearman, Peter