Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes
Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes
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自我驱动记忆表型CD4 T淋巴细胞的稳态和免疫功能
DOI：
10.1080/25785826.2022.2129370
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kawabe T
中科院分区：
文献类型：
--
作者：
Fukutani Atsuki;Herzog Walter;Kawabe T
CD4+T淋巴细胞在适应性免疫应答中起重要作用。在病原体感染中，naïve对外来抗原有强烈反应的CD4+T细胞迅速增殖分化为效应/记忆细胞，有助于消除相关病原体。除了这种传统的T细胞激活途径外，naïve T细胞也可以对外周自身抗原产生弱反应，通过稳态稳态增殖自发获得记忆表型。这种“记忆表型”（MP） CD4+T淋巴细胞在标记物表达方面与外源抗原特异性记忆细胞不同。一旦生成，MP细胞通过快速增殖维持，同时分化为T-bet+ ' MP1 '亚群，后者的反应由1型树突状细胞稳态产生的IL-12促进。重要的是，MP1细胞具有先天免疫功能；它们可以产生IFN-γ来响应IL-12和IL-18，帮助宿主防御病原体。同样，rorγ - t+ ‘ MP17 ‘和Gata3hi ’ mp2 ’细胞的存在及其潜在的免疫功能也被提出。在这篇综述中，我将讨论我们目前对MP CD4+T淋巴细胞产生、维持和分化的独特机制及其在各种疾病条件下的功能意义的理解。
CD4+T lymphocytes play an essential role in adaptive immune responses. In pathogen infection, naïve CD4+T cells that strongly respond to foreign antigens robustly proliferate to differentiate into effector/memory cells, contributing to elimination of the pathogen concerned. In addition to this conventional T cell activation pathway, naïve T cells can also weakly respond to self antigens in the periphery to spontaneously acquire a memory phenotype through homeostatic proliferation in steady state. Such ‘memory-phenotype’ (MP) CD4+T lymphocytes are distinguishable from foreign antigen-specific memory cells in terms of marker expression. Once generated, MP cells are maintained by rapid proliferation while differentiating into the T-bet+‘MP1’ subset, with the latter response promoted by IL-12 homeostatically produced by type 1 dendritic cells. Importantly, MP1 cells possess innate immune function; they can produce IFN-γ in response to IL-12 and IL-18 to contribute to host defense against pathogens. Similarly, the presence of RORγt+‘MP17’ and Gata3hi‘MP2’ cells as well as their potential immune functions have been proposed. In this review, I will discuss our current understanding on the unique mechanisms of generation, maintenance, and differentiation of MP CD4+T lymphocytes as well as their functional significance in various disease conditions.
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影响因子：
4.4
作者：
J. Byrne;A. Stanković;M. Cooper
通讯作者：
J. Byrne;A. Stanković;M. Cooper
记忆表型细胞：天然产生的具有先天免疫功能的CD4 T淋巴细胞
DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
平田 祐介;蘆田 諒;野口 拓也;松沢 厚;Koike S;Eikan Mishima;Takeshi Kawabe
通讯作者：
Takeshi Kawabe
表型和功能分析揭示了自我驱动记忆表型 CD4 T 淋巴细胞是与外来抗原特异性记忆细胞不同的异质群体。
DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
Takeshi Kawabe;Thomas Ciucci;Kwang Soon Kim;Shunichi Tayama;Akihisa Kawajiri;Naoto Ishii;Dragana Jankovic;Jinfang Zhu;Jonathan Sprent;Remy Bosselut;Alan Sher
通讯作者：
Alan Sher
影响因子：
5.5
作者：
Park, JS;Gamboni-Robertson, F;Abraham, E
通讯作者：
Abraham, E
影响因子：
32.4
作者：
Martin, Christopher E.;Spasova, Darina S.;Surh, Charles D.
通讯作者：
Surh, Charles D.