CIGene: a literature-based online resource for cancer initiation genes.
CIGene: a literature-based online resource for cancer initiation genes.
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CIGene：基于文献的癌症起始基因在线资源
DOI：
10.1186/s12864-018-4944-y
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发表时间：
2018-07-25
期刊：
影响因子：
4.4
通讯作者：
Qu H
中科院分区：
文献类型：
--
作者：
Liu Y;Luo M;Li Q;Lu J;Zhao M;Qu H
背景癌症起始基因（cancer initiation genes，CIG）是直接促进细胞增殖或诱发癌症的基因。有数以千计的已发表的研究确定各种CIG，但是，没有系统的收集或描述是available.ResultsTo构建CIG参考遗传筛查，我们收集了177人类基因策展从1507 PubMed摘要。为了便于数据查询和浏览，将所鉴定的CIG连同广泛的生物信息学注释一起沿着存储在称为CIGene的在线数据库中。初步的功能分析揭示了一个被忽视的作用，细胞运动在癌症的启动。随后交叉参考已知的肿瘤抑制基因和癌基因对177 CIG确定96和81 CIG与和不知道致癌作用，分别。对所有177个CIG的连续网络分析确定，这两组基因更有可能在其组内链接。功能研究也证实了这些基团的不同分子功能。虽然96个已知的致癌基因在基因调控和信号传导中起着重要作用，但其余81个基因具有更多的辅助功能，例如增强子结合。对96个已知致癌基因的进一步网络和突变分析显示，这些基因的突变在多种癌症中高度普遍。通过专注于乳腺癌，我们发现，32的96个基因与突变的乳腺癌显着相关的患者survival.ConclusionsAs的第一个基于文献的在线资源CIGs，CIGene将作为一个有用的门户系统分析癌症的启动。CIGene免费提供给所有学术用户， http://soft.bioinfo-minzhao.org/cigene/ .
BackgroundCancer initiation genes (CIGs) are genes that can directly promote cell proliferation or induce cancer. There are thousands of published studies identifying various CIGs; however, no systematic collection or description is available.ResultsTo construct a CIG reference for genetic screening, we have collected 177 human genes curated from 1507 PubMed abstracts. To facilitate data queries and browsing, the identified CIGs along with extensive bioinformatic annotations were stored in an online database called CIGene. Initial functional analysis revealed an overlooked role for cell motility in cancer initiation. Subsequent cross-referencing of known tumor suppressor genes and oncogenes against the 177 CIGs identified 96 and 81 CIGs with and without known oncogenic roles, respectively. Successive network analyses of all 177 CIGs determined that the two groups of genes were more likely to link within their group. The distinct molecular functions for these groups were also confirmed with functional studies. While the 96 known oncogenic genes had fundamental roles in gene regulation and signaling, the remaining 81 genes possessed more ancillary functions, such enhancer binding. Further network and mutational analysis of the 96 known oncogenic genes revealed that mutations in these genes were highly prevalent in multiple cancers. By focusing on breast cancer, we found that 32 of the 96 genes with mutations in breast cancers were significantly associated with patient survival.ConclusionsAs the first literature-based online resource for CIGs, CIGene will serve as a useful gateway for the systematic analysis of cancer initiation. CIGene is freely available to all academic users at http://soft.bioinfo-minzhao.org/cigene/ .
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影响因子：
14.9
作者：
Lee, Tzong-Yi;Huang, Hsien-Da;Hung, Jui-Hung;Huang, Hsi-Yuan;Yang, Yuh-Shyong;Wang, Tzu-Hao
通讯作者：
Wang, Tzu-Hao
影响因子：
64.8
作者：
Greaves, Mel;Maley, Carlo C.
通讯作者：
Maley, Carlo C.
影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y
影响因子：
5.8
作者：
Liu, Yining;Zhao, Min
通讯作者：
Zhao, Min
影响因子：
3.7
作者：
Jin Y;Turaev D;Weinmaier T;Rattei T;Makse HA
通讯作者：
Makse HA