Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors.
Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors.
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DOI：
10.1007/s00330-009-1394-6
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发表时间：
2009-09
影响因子：
5.9
通讯作者：
van der Lugt A
中科院分区：
文献类型：
--
作者：
Rozie S;de Weert TT;de Monyé C;Homburg PJ;Tanghe HL;Dippel DW;van der Lugt A
本研究的目的是检查有症状的颈动脉粥样硬化斑块的体积和成分，并调查这些斑块特征与狭窄的严重程度和心血管危险因素的存在之间的关系。100例有脑血管症状的患者接受了CT血管造影。我们测量了斑块体积（PV）和斑块成分（钙化、纤维组织和脂质）在有症状动脉中的相对贡献。不同组分的贡献被测量为HU值的限定范围内的体素的数量（钙化>130 HU，纤维组织60-130 HU，脂质核心<60 HU）。57例患者在症状性颈动脉中有动脉粥样硬化斑块。狭窄程度与肺静脉中度相关。年龄和吸烟与PV独立相关。与非高胆固醇血症患者相比，高胆固醇血症患者的斑块中脂质含量明显减少，钙含量增加。其他心血管危险因素与肺静脉或斑块成分无显著相关性。颈动脉管腔狭窄部分反映了动脉粥样硬化性颈动脉疾病的数量。斑块体积和斑块组成与心血管危险因素相关。
The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. We measured plaque volume (PV) and the relative contribution of plaque components (calcifications, fibrous tissue, and lipid) in the symptomatic artery. The contribution of different components was measured as the number of voxels within defined ranges of HU values (calcification >130 HU, fibrous tissue 60–130 HU, lipid core <60 HU). Fifty-seven patients had atherosclerotic plaque in the symptomatic carotid artery. The severity of stenosis and PV were moderately correlated. Age and smoking were independently related to PV. Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia. Other cardiovascular risk factors were not significantly related to PV or plaque composition. Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease. Plaque volume and plaque composition are associated with cardiovascular risk factors.
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影响因子：
37.8
作者：
Mauriello, A;Sangiorgi, G;Spagnoli, LG
通讯作者：
Spagnoli, LG
影响因子：
19.7
作者：
de Monyé, C;Cademartiri, F;van Der Lugt, A
通讯作者：
van Der Lugt, A
影响因子：
24
作者：
Nicholls, Stephen J.;Tuzcu, E. Murat;Nissen, Steven E.
通讯作者：
Nissen, Steven E.
影响因子：
5.3
作者：
Saam, Tobias;Yuan, Chun;Hatsukami, Thomas S.
通讯作者：
Hatsukami, Thomas S.
影响因子：
8.7
作者：
Zhao, XQ;Yuan, C;Brown, BG
通讯作者：
Brown, BG