Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson's disease patients.
Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson's disease patients.
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DOI：
10.1186/s40035-022-00280-7
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发表时间：
2022-02-07
影响因子：
12.6
通讯作者：
Chen SD
中科院分区：
文献类型：
--
作者：
Li G;Huang P;Cui SS;Tan YY;He YC;Shen X;Jiang QY;Huang P;He GY;Li BY;Li YX;Xu J;Wang Z;Chen SD
太极拳已被证明可以改善帕金森病（PD）的运动症状，但其长期效果和相关机制仍有待阐明。在这项研究中，我们调查了长期太极拳训练对PD运动症状的影响及其机制。将95例早期PD患者随机分为太极拳组（n = 32）、快走组（n = 31）和非运动组（n = 32）。在基线、干预6个月和12个月时，所有参与者均接受贝格平衡量表（BBS）、统一PD评分量表（UMRS）、定时起身和行走试验（TUG）和三维步态分析、功能磁共振成像（fMRI）、血浆细胞因子和代谢组学分析以及血液亨廷顿相互作用蛋白2（HIP 2）mRNA水平分析。使用重复测量ANOVA计算纵向自我变化。GEE（广义估计方程）被用来评估与评定量表纵向数据相关的因素。转换率用于fMRI分析。错误发现率校正用于多重校正。太极组的受试者在BBS、TUG和步宽上表现更好。此外，太极拳在改善BBS和步宽方面优于快走。BBS改善与视觉网络功能增强和白细胞介素-1 β下调相关。BRAS的改善与增强的默认模式网络功能、降低的L-苹果酸和3-磷酸甘油酸以及增加的腺苷和HIP2 mRNA水平相关。此外，精氨酸的生物合成，尿素循环，三羧酸循环和极长链脂肪酸的β氧化也通过太极拳训练得到改善。长期太极拳训练可改善PD患者的运动功能，尤其是步态和平衡。潜在的机制可能包括增强脑网络功能，减少炎症，改善氨基酸代谢，能量代谢和神经递质代谢，以及降低对多巴胺能变性的脆弱性。试验注册本研究已在中国临床试验注册中心注册（注册号：ChiCTR 2000036036;注册日期：2020年8月22日）。在线版本包含补充材料，可通过10.1186/s40035 - 022 - 00280 - 7获得。
Tai Chi has been shown to improve motor symptoms in Parkinson’s disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-term Tai Chi training on motor symptoms in PD and the underlying mechanisms. Ninety-five early-stage PD patients were enrolled and randomly divided into Tai Chi (n = 32), brisk walking (n = 31) and no-exercise (n = 32) groups. At baseline, 6 months and 12 months during one-year intervention, all participants underwent motor symptom evaluation by Berg balance scale (BBS), Unified PD rating-scale (UPDRS), Timed Up and Go test (TUG) and 3D gait analysis, functional magnetic resonance imaging (fMRI), plasma cytokine and metabolomics analysis, and blood Huntingtin interaction protein 2 (HIP2) mRNA level analysis. Longitudinal self-changes were calculated using repeated measures ANOVA. GEE (generalized estimating equations) was used to assess factors associated with the longitudinal data of rating scales. Switch rates were used for fMRI analysis. False discovery rate correction was used for multiple correction. Participants in the Tai Chi group had better performance in BBS, UPDRS, TUG and step width. Besides, Tai Chi was advantageous over brisk walking in improving BBS and step width. The improved BBS was correlated with enhanced visual network function and downregulation of interleukin-1β. The improvements in UPDRS were associated with enhanced default mode network function, decreased L-malic acid and 3-phosphoglyceric acid, and increased adenosine and HIP2 mRNA levels. In addition, arginine biosynthesis, urea cycle, tricarboxylic acid cycle and beta oxidation of very-long-chain fatty acids were also improved by Tai Chi training. Long-term Tai Chi training improves motor function, especially gait and balance, in PD. The underlying mechanisms may include enhanced brain network function, reduced inflammation, improved amino acid metabolism, energy metabolism and neurotransmitter metabolism, and decreased vulnerability to dopaminergic degeneration. Trial registration This study has been registered at Chinese Clinical Trial Registry (Registration number: ChiCTR2000036036; Registration date: August 22, 2020). The online version contains supplementary material available at 10.1186/s40035-022-00280-7.
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DOI：
10.1155/2013/502131
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Lan C;Chen SY;Lai JS;Wong AM
通讯作者：
Wong AM
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
11
作者：
Hatano, Taku;Saiki, Shinji;Hattori, Nobutaka
通讯作者：
Hattori, Nobutaka
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.
DOI：
10.1073/pnas.0610204104
发表时间：
2007-01-16
影响因子：
11.1
作者：
Scherzer, Clemens R.;Eklund, Aron C.;Gullans, Steven R.
通讯作者：
Gullans, Steven R.