Dual-hemisphere tDCS facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation.
Dual-hemisphere tDCS facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation.
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DOI：
10.1186/1471-2202-9-103
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发表时间：
2008-10-28
期刊：
影响因子：
2.4
通讯作者：
Schlaug, Gottfried
中科院分区：
文献类型：
--
作者：
Vines, Bradley W.;Cerruti, Carlo;Schlaug, Gottfried
经颅直流电刺激（tDCS）是一种非侵入性技术，已被发现可以调节大脑中神经元的兴奋性。施加到头皮的电流的极性决定了tDCS对底层组织的影响：阳极tDCS增加兴奋性，而阴极tDCS降低兴奋性。研究表明，将阳极tDCS应用于非优势运动皮层可以改善非优势手的运动性能，可能是通过改变神经元之间的突触可塑性。我们以前的研究还表明，应用阴极tDCS的优势运动皮层，可以提高性能的非优势手，这种效果可能是由于调制抑制性预测（半球间抑制）之间的运动皮层的两个半球。我们假设，与仅刺激非优势运动皮层相比，在优势运动皮层上施加阴极tDCS和在非优势运动皮层上施加阳极tDCS的刺激对非优势手的手指序列性能具有更大的影响。16名右利手参与者接受了三种刺激条件：1）双半球-在非优势运动皮层上具有阳极tDCS，在优势运动皮层上具有阴极tDCS，2）单半球-在非优势运动皮层上具有阳极tDCS，以及3）假tDCS。参与者在每次刺激之前和之后用非优势手进行手指排序任务。因变量是比较tDCS前后评分的性能变化百分比。重复测量ANOVA得出tDCS条件的显著影响（F（2，30）= 4.468，p = 0.037）。事后分析显示，双半球刺激比单半球刺激（p = 0.021）和假刺激（p = 0.041）显著改善了性能。我们建议，同时应用阴极tDCS的优势运动皮层和阳极tDCS的非优势运动皮层产生的附加效应，这有利于在非优势手的运动性能。这些发现与运动技能学习和中风后运动恢复的研究有关。
Transcranial direct current stimulation (tDCS) is a non-invasive technique that has been found to modulate the excitability of neurons in the brain. The polarity of the current applied to the scalp determines the effects of tDCS on the underlying tissue: anodal tDCS increases excitability, whereas cathodal tDCS decreases excitability. Research has shown that applying anodal tDCS to the non-dominant motor cortex can improve motor performance for the non-dominant hand, presumably by means of changes in synaptic plasticity between neurons. Our previous studies also suggest that applying cathodal tDCS over the dominant motor cortex can improve performance for the non-dominant hand; this effect may result from modulating inhibitory projections (interhemispheric inhibition) between the motor cortices of the two hemispheres. We hypothesized that stimultaneously applying cathodal tDCS over the dominant motor cortex and anodal tDCS over the non-dominant motor cortex would have a greater effect on finger sequence performance for the non-dominant hand, compared to stimulating only the non-dominant motor cortex. Sixteen right-handed participants underwent three stimulation conditions: 1) dual-hemisphere – with anodal tDCS over the non-dominant motor cortex, and cathodal tDCS over the dominant motor cortex, 2) uni-hemisphere – with anodal tDCS over the non-dominant motor cortex, and 3) sham tDCS. Participants performed a finger-sequencing task with the non-dominant hand before and after each stimulation. The dependent variable was the percentage of change in performance, comparing pre- and post-tDCS scores. A repeated measures ANOVA yielded a significant effect of tDCS condition (F(2,30) = 4.468, p = .037). Post-hoc analyses revealed that dual-hemisphere stimulation improved performance significantly more than both uni-hemisphere (p = .021) and sham stimulation (p = .041). We propose that simultaneously applying cathodal tDCS over the dominant motor cortex and anodal tDCS over the non-dominant motor cortex produced an additive effect, which facilitated motor performance in the non-dominant hand. These findings are relevant to motor skill learning and to research studies of motor recovery after stroke.
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