Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging.

Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging.
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DOI:
10.1039/c0an00466a
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发表时间:
2010-11
期刊:
The Analyst
影响因子:
--
通讯作者:
Cheng Q
Cheng Q
中科院分区:
其他
文献类型:
--
作者:
Linman MJ;Abbas A;Cheng Q

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自1990年代初期表面等离子体共振(SPR)和SPR成像(SPRI)的出现以来,它们在生物分子相互作用分析(BIA)中的使用已经显着扩展。 SPR传感器开发中的一个重要研究领域是设计新型有效界面的设计,这些界面允许以高度选择性和敏感的方式探测各种化学和生物学相互作用。精心设计且健壮的界面是获得准确且相关的生物学信息的必要性。这篇评论涵盖了该领域的最新研究工作,特别关注生物区域,新的SPR生物传感材料以及用于SPR成像的新型阵列设计。讨论了有关前进和下一步的SPR技术挑战的观点。
Ever since the advent of surface plasmon resonance (SPR) and SPR imaging (SPRi) in the early 1990s, their use in biomolecular interaction analysis (BIA) has expanded phenomenally. An important research area in SPR sensor development is the design of novel and effective interfaces that allow for the probing of a variety of chemical and biological interactions in a highly selective and sensitive manner. A well-designed and robust interface is a necessity to obtain both accurate and pertinent biological information. This review covers the recent research efforts in this area with a specific focus towards biointerfaces, new materials for SPR biosensing, and novel array designs for SPR imaging. Perspectives on the challenges ahead and next steps for SPR technology are discussed.
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