High prevalence and genetic diversity of HCV among HIV-1 infected people from various high-risk groups in China.
High prevalence and genetic diversity of HCV among HIV-1 infected people from various high-risk groups in China.
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DOI：
10.1371/journal.pone.0010631
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发表时间：
2010-05-27
期刊：
影响因子：
3.7
通讯作者：
Yu XF
中科院分区：
文献类型：
--
作者：
Shang H;Zhong P;Liu J;Han X;Dai D;Zhang M;Zhao K;Xu R;Yu XF
人类免疫缺陷病毒1型（HIV - 1）和丙型肝炎病毒（HCV）的合并感染是一个重大的全球公共卫生问题，也是抗HIV - 1治疗的一个主要考虑因素。在中国新启动的全国性抗HIV - 1治疗项目中，符合条件的HIV - 1阳性人群中的HCV感染情况尚未得到很好的描述。
对来自中国包括受影响最严重的四个省份在内的多个省份的HIV - 1阳性注射吸毒者（IDU）、既往有偿献血者（FBD）和性传播病例进行了一项全国性调查。确定了HCV的流行率和基因多样性。我们发现注射吸毒者和既往有偿献血者的HCV感染率极高（分别为97%和93%）。令人惊讶的是，通过性接触感染HIV - 1的人群的HCV感染率（20%）也高于普通人群。在中国中部到东北部多个省份的既往有偿献血者中，HIV - 1亚型和HCV基因型惊人地相似。然而，尽管在注射吸毒者中可以检测到海洛因的陆路贩运模式和不同的HIV - 1亚型，但注射吸毒者的HCV基因型更加多样化，并表现出显著的地域差异。
中国新出现的HIV - 1和HCV合并感染以及HCV可能的性传播需要紧急的预防措施，并应在全国抗逆转录病毒治疗项目中加以考虑。
Co-infection with HIV-1 and HCV is a significant global public health problem and a major consideration for anti-HIV-1 treatment. HCV infection among HIV-1 positive people who are eligible for the newly launched nationwide anti-HIV-1 treatment program in China has not been well characterized. A nationwide survey of HIV-1 positive injection drug uses (IDU), former paid blood donors (FBD), and sexually transmitted cases from multiple provinces including the four most affected provinces in China was conducted. HCV prevalence and genetic diversity were determined. We found that IDU and FBD have extremely high rates of HCV infection (97% and 93%, respectively). Surprisingly, people who acquired HIV-1 through sexual contact also had a higher rate of HCV infection (20%) than the general population. HIV-1 subtype and HCV genotypes were amazingly similar among FBD from multiple provinces stretching from Central to Northeast China. However, although patterns of overland trafficking of heroin and distinct HIV-1 subtypes could be detected among IDU, HCV genotypes of IDU were more diverse and exhibited significant regional differences. Emerging HIV-1 and HCV co-infection and possible sexual transmission of HCV in China require urgent prevention measures and should be taken into consideration in the nationwide antiretroviral treatment program.
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