The effect of sex on social cognition and functioning in schizophrenia.
The effect of sex on social cognition and functioning in schizophrenia.
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DOI：
10.1038/s41537-021-00188-7
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发表时间：
2021-12-01
影响因子：
5.4
通讯作者：
Lee J
中科院分区：
文献类型：
--
作者：
Ferrer-Quintero M;Green MF;Horan WP;Penn DL;Kern RS;Lee J
社会认知障碍是精神分裂症的一个核心特征，在这种疾病的社区功能不良中起着关键作用。然而，我们对精神分裂症中关键生物学变量与社会认知障碍之间关系的理解是有限的。本研究旨在探讨性别对精神分裂症患者社会认知功能损害程度的影响以及社会认知功能损害与社会功能的关系。248名精神分裂症患者（61名女性）和87名健康对照者（31名女性）完成了社会认知的五项客观测量和一项主观测量。客观测量包括面部情感识别、生物运动中的情绪、自我参照记忆、MSCEIT分支4和移情准确性任务。主观测量是人际反应指数（IRI），其中包括四个分量表。患者完成了社会和非社会功能能力和社区功能的措施。对于客观的社会认知任务，我们发现一个显着的性别差异，只有一个措施，MSCEIT分支4，其中在患者和对照组，女性表现优于男性。关于IRI，女性赞同较高的同情相关项目的一个分量表。性别的调节作用，发现只有客观的社会认知和非社会功能能力之间的关联。男性患者的相关性强于女性患者。在这项研究中，我们发现在主观和客观的测量中，性别对精神分裂症患者社会认知的影响的证据很少。性别似乎并没有缓和社会认知和精神分裂症功能之间的关联。
Social cognitive impairment is a core feature of schizophrenia and plays a critical role in poor community functioning in the disorder. However, our understanding of the relationship between key biological variables and social cognitive impairment in schizophrenia is limited. This study examined the effect of sex on the levels of social cognitive impairment and the relationship between social cognitive impairment and social functioning in schizophrenia. Two hundred forty-eight patients with schizophrenia (61 female) and 87 healthy controls (31 female) completed five objective measures and one subjective measure of social cognition. The objective measures included the Facial Affect Identification, Emotion in Biological Motion, Self-Referential Memory, MSCEIT Branch 4, and Empathic Accuracy tasks. The subjective measure was the Interpersonal Reactivity Index (IRI), which includes four subscales. Patients completed measures of social and non-social functional capacity and community functioning. For objective social cognitive tasks, we found a significant sex difference only on one measure, the MSCEIT Branch 4, which in both patient and control groups, females performed better than males. Regarding the IRI, females endorsed higher empathy-related items on one subscale. The moderating role of sex was found only for the association between objective social cognition and non-social functional capacity. The relationship was stronger in male patients than female patients. In this study, we found minimal evidence of a sex effect on social cognition in schizophrenia across subjective and objective measures. Sex does not appear to moderate the association between social cognition and functioning in schizophrenia.
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