A multi-layered poroelastic slab model under cyclic loading for a single osteon.
A multi-layered poroelastic slab model under cyclic loading for a single osteon.
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单骨循环加载下的多层多孔弹性板模型
DOI：
10.1186/s12938-018-0528-y
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发表时间：
2018-07-17
影响因子：
3.9
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Chen Y;Wang W;Ding S;Wang X;Chen Q;Li X
骨小梁由多层骨基质和腔隙-小管系统中的间质液体组成。负荷诱导的骨间质液在骨陷窝-骨管系统中的流动是骨细胞机械转导和骨重建的关键。为了研究骨素的层状结构和非均质材料性质对间隙流体流动和渗流速度分布的影响，将骨素理想化为循环载荷作用下的中空二维孔弹性多层板模型。基于孔弹性理论，得到了缝隙-孔道孔隙中间隙流体压力和渗流速度的解析解。结果表明，应变大小对间隙流体压力的影响大于加载频率。有趣的是，渗透率的不均匀分布在皮质骨横截面上引起了组织间流体压力和渗流速度的显著变化。此外，对骨细胞的间质流体流动刺激主要由骨表面的渗透率值控制，而不是由骨内壁的渗透率控制。循环加载刺激引起的骨间质液流动不仅与应变幅值和加载频率有关，而且与渗透率的空间梯度分布密切相关。该模型可以帮助我们更好地理解骨重建过程中对骨细胞的液体流动刺激。
An osteon consists of a multi-layered bone matrix and interstitial fluid flow in the lacunar–canalicular system. Loading-induced interstitial fluid flow in the lacunar–canalicular system is critical for osteocyte mechanotransduction and bone remodelling. To investigate the effects of the lamellar structure and heterogeneous material properties of the osteon on the distributions of interstitial fluid flow and seepage velocity, an osteon is idealized as a hollow two-dimensional poroelastic multi-layered slab model subjected to cyclic loading. Based on poroelastic theory, the analytical solutions of interstitial fluid pressure and seepage velocity in lacunar–canalicular pores were obtained. The results show that strain magnitude has a greater influence on interstitial fluid pressure than loading frequency. Interestingly, the heterogeneous distribution of permeability produces remarkable variations in interstitial fluid pressure and seepage velocity in the cross-section of cortical bone. In addition, interstitial fluid flow stimuli to osteocytes are mostly controlled by the value of permeability at the surface of the osteon rather than at the inner wall of the osteon. Interstitial fluid flow induced by cycling loading stimuli to an osteocyte housed in a lacunar–canalicular pore is not only correlated with strain amplitude and loading frequency, but also closely correlated with the spatial gradient distribution of permeability. This model can help us better understand the fluid flow stimuli to osteocytes during bone remodelling.
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DOI：
10.1016/s0020-7683(98)00101-2
发表时间：
1998-12-01
影响因子：
3.6
作者：
Abousleiman, Y;Cui, L
通讯作者：
Cui, L
DOI：
10.1163/157361109789017005
发表时间：
2009-01-01
影响因子：
2
作者：
Nguyen, V. -H.;Lemaire, T.;Naili, S.
通讯作者：
Naili, S.
影响因子：
3.5
作者：
Benalla, M.;Cardoso, L.;Cowin, S. C.
通讯作者：
Cowin, S. C.
影响因子：
3.5
作者：
Vu-Hieu Nguyen;Lemaire, Thibault;Naili, Salah
通讯作者：
Naili, Salah
影响因子：
2.4
作者：
Fritton, SP;McLeod, KJ;Rubin, CT
通讯作者：
Rubin, CT