Making choice between competing rewards in uncertain vs. safe social environment: role of neuronal nicotinic receptors of acetylcholine.
Making choice between competing rewards in uncertain vs. safe social environment: role of neuronal nicotinic receptors of acetylcholine.
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DOI：
10.3389/fnhum.2013.00468
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发表时间：
2013
影响因子：
2.9
通讯作者：
Granon S
中科院分区：
文献类型：
--
作者：
Chabout J;Cressant A;Hu X;Edeline JM;Granon S
在社会环境中，在多种回报之间的选择受到情况不确定性的影响。在这里，我们比较了小鼠如何与同种小鼠互动，以及它们在三室任务(没有社会威胁可能)和社交互动任务SIT(两只小鼠自由互动时的不确定情况)中如何在这种互动中使用声音通信。我们进一步操纵了老鼠的动机状态，看看它们如何对自然奖励进行排名，比如社交、食物和寻求新奇。我们之前已经证明，含有尼古丁受体的β2亚基-β2*nAChRs-是在高度不确定性的社会情景中建立社交互动、新奇探索和食物消费之间的奖励排名所必需的。β2*nAChRs基因敲除小鼠-β2−/−小鼠-与对照WT小鼠相比，在做出社会灵活性选择方面表现出严重的损害。我们目前的数据显示，与更不确定的环境相比，在社会安全的环境中面对同种动物，大大减少了两只小鼠之间的交流，并改变了它们处理社会同种动物的方式。此外，我们首次证明，当β2−/−小鼠被放置在社会安全的环境中时，其动机排名与WT小鼠相同。因此，β2*nAChR对于整合社会信息或社会奖励本身并不是必需的，但只有在社会不确定的环境中才对做出选择很重要。在社会神经科学的背景下，这似乎特别重要，因为许多动物模型被用来提供新的见解，并测试对影响社会和交流过程的人类疾病有希望的新疗法，其中包括自闭症谱系障碍和精神分裂症。
In social environments, choosing between multiple rewards is modulated by the uncertainty of the situation. Here, we compared how mice interact with a conspecific and how they use acoustic communication during this interaction in a three chambers task (no social threat was possible) and a Social Interaction Task, SIT (uncertain situation as two mice interact freely). We further manipulated the motivational state of the mice to see how they rank natural rewards such as social contact, food, and novelty seeking. We previously showed that beta2-subunit containing nicotinic receptors-β2*nAChRs- are required for establishing reward ranking between social interaction, novelty exploration, and food consumption in social situations with high uncertainty. Knockout mice for β2*nAChRs-β2−/−mice- exhibit profound impairment in making social flexible choices, as compared to control -WT- mice. Our current data shows that being confronted with a conspecific in a socially safe environment as compared to a more uncertain environment, drastically reduced communication between the two mice, and changed their way to deal with a social conspecific. Furthermore, we demonstrated for the first time, that β2−/− mice had the same motivational ranking than WT mice when placed in a socially safe environment. Therefore, β2*nAChRs are not necessary for integrating social information or social rewards per se, but are important for making choices, only in a socially uncertain environment. This seems particularly important in the context of Social Neuroscience, as numerous animal models are used to provide novel insights and to test promising novel treatments of human pathologies affecting social and communication processes, among which Autistic spectrum disorders and schizophrenia.
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影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
4.8
作者：
Avale, Maria Elena;Chabout, Jonathan;Granon, Sylvie
通讯作者：
Granon, Sylvie
DOI：
10.1073/pnas.0807635105
发表时间：
2008-10-14
影响因子：
11.1
作者：
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通讯作者：
Maskos, Uwe
影响因子：
3.7
作者：
Chabout J;Serreau P;Ey E;Bellier L;Aubin T;Bourgeron T;Granon S
通讯作者：
Granon S
影响因子：
4.7
作者：
Chadman, Kathryn K.;Gong, Shiaoching;Crawley, Jacqueline N.
通讯作者：
Crawley, Jacqueline N.