Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment.
Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment.
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DOI：
10.1371/journal.pone.0029401
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Granon S
中科院分区：
文献类型：
--
作者：
Chabout J;Serreau P;Ey E;Bellier L;Aubin T;Bourgeron T;Granon S
小鼠的社会互动经常在转基因品系中进行分析，以了解影响社会互动的障碍，如自闭症谱系障碍。不同类型的社会互动已经被描述，主要是女性和幼崽之间，以及成年男性和女性之间。然而，我们最近表明，成年男性之间的社会互动也可以包括认知和动机特征。在社会交往中，啮齿动物发出超声波发声（USVs），但它仍然是未知的，如果调用类型不同的使用取决于上下文，如果它们与动机状态。在这里，我们记录了成年C57 BL/6 J雄性小鼠在各种行为条件下的叫声，如社会互动，新奇探索和束缚应激。我们介绍了一个调制器的动机状态，通过比较男性保持隔离和男性保持在实验前的组。雄性小鼠在所有社交和非社交情况下都会发出USV，甚至在压力很大的约束环境中也会发出USV。然而，他们发出的呼叫数量最重要，在社会交往中呼叫类型的多样性最大，特别是当表现出高度的社会联系动机时。对于保持社会隔离的小鼠，记录的呼叫数量与社会接触的持续时间呈正相关，并且大多数呼叫是在两只小鼠之间的接触期间发出的。在分组饲养的小鼠中未观察到这种相关性。这些结果为更深入地理解和表征与社交互动相关的声学信号开辟了道路。它们还可以帮助评估激励状态在声学信号发射中的作用。
Social interactions in mice are frequently analysed in genetically modified strains in order to get insight of disorders affecting social interactions such as autism spectrum disorders. Different types of social interactions have been described, mostly between females and pups, and between adult males and females. However, we recently showed that social interactions between adult males could also encompass cognitive and motivational features. During social interactions, rodents emit ultrasonic vocalizations (USVs), but it remains unknown if call types are differently used depending of the context and if they are correlated with motivational state. Here, we recorded the calls of adult C57BL/6J male mice in various behavioral conditions, such as social interaction, novelty exploration and restraint stress. We introduced a modulator for the motivational state by comparing males maintained in isolation and males maintained in groups before the experiments. Male mice uttered USVs in all social and non-social situations, and even in a stressful restraint context. They nevertheless emitted the most important number of calls with the largest diversity of call types in social interactions, particularly when showing a high motivation for social contact. For mice maintained in social isolation, the number of calls recorded was positively correlated with the duration of social contacts, and most calls were uttered during contacts between the two mice. This correlation was not observed in mice maintained in groups. These results open the way for a deeper understanding and characterization of acoustic signals associated with social interactions. They can also help evaluating the role of motivational states in the emission of acoustic signals.
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