Enhancement by calcium of the invasiveness of Salmonella for HeLa cell monolayers.

Enhancement by calcium of the invasiveness of Salmonella for HeLa cell monolayers.
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钙增强沙门氏菌对 HeLa 细胞单层的侵袭力。

DOI:
10.1093/cid/10.supplement_2.s319
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发表时间:
1988
期刊:
Reviews of infectious diseases
影响因子:
--
通讯作者:
Niesel,DW
Niesel,DW
中科院分区:
--
文献类型:
--
作者:
Peterson,JW;Niesel,DW

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An outer membrane-associated cytotoxin and the invasive capacity of Salmonella were shown to be modulated by divalent cations. Cell detachment activity of salmonella cytotoxin was blocked by addition of either Ca⁺⁺ or Mg⁺⁺. It is interesting that Ca⁺⁺ but not other divalent cations was shown to enhance the invasiveness of Salmonella for HeLa cell monolayers. The dose-dependent Ca⁺⁺ effect required metabolism and was not simply the result of Ca⁺⁺ binding to the surface of the bacteria. These data suggest a possible role of divalent cations in the unique relationship of invasive bacteria and host cells.
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