Potential functions of esophageal cancer-related gene-4 in the cardiovascular system
Potential functions of esophageal cancer-related gene-4 in the cardiovascular system
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食管癌相关基因4在心血管系统中的潜在功能
DOI：
10.1007/s11684-019-0701-0
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发表时间：
2019-08
影响因子：
8.1
通讯作者：
Dang Xitong
中科院分区：
文献类型：
--
作者：
Zhou Rui;Liu Yuanshu;Huang Wenjun;Dang Xitong
食管癌相关基因4 （Ecrg4）是从食管正常上皮中克隆出来的。它在静止上皮细胞中组成性表达，在肿瘤发生过程中下调表达，并且Ecrg4的表达水平与肿瘤细胞的恶性表型呈负相关，验证了Ecrg4是一个真正的肿瘤抑制基因。与其他通常编码膜或细胞内蛋白的肿瘤抑制基因不同，Ecrg4编码一种含有148个氨基酸的前肽，该前肽在上皮细胞、特化上皮细胞和人类白细胞中拴在细胞表面，在细胞激活时可以依赖地将组织加工成几个小肽。Ecrg4在许多其他细胞/组织中表达，包括心肌细胞和心脏传导系统、颈动脉体的血管球细胞、肾上腺、脉络膜丛和白细胞等，在这些细胞/组织中发挥不同的功能，如促进/抑制炎症、诱导神经元衰老、刺激下丘脑-垂体-肾上腺轴、维持干细胞的干性、参与心脏的节律和速率控制。除了抑制肿瘤外，还可能测量心血管系统（CVS）对缺氧的反应。在这里，我们简要回顾了Ecrg4的最新发现及其作为肿瘤抑制因子的潜在分子机制，并重点介绍了Ecrg4在CVS中的新作用。
Esophageal cancer-related gene-4 (Ecrg4) is cloned from the normal epithelium of the esophagus. It is constitutively expressed in quiescent epithelial cells and downregulated during tumorigenesis, and Ecrg4 expression levels are inversely correlated with the malignant phenotype of tumor cells, validating that Ecrg4 is a real tumor suppressor gene. Unlike other tumor suppressor genes that usually encode membrane or intracellular proteins, Ecrg4 encodes a 148-amino acid pre-pro-peptide that is tethered on the cell surface in epithelial cells, specialized epithelial cells, and human leukocytes, where it can be processed tissue dependently into several small peptides upon cell activation. Ecrg4 is expressed in a wide variety of other cells/tissues, including cardiomyocytes and conduction system of the heart, the glomus cells of the carotid body, adrenal glands, choroid plexus, and leukocytes among others, where it exerts distinct functions, such as promoting/suppressing inflammation, inducing neuron senescence, stimulating the hypothalamus-pituitary-adrenal axis, maintaining the stemness of stem cells, participating in the rhythm and rate control of the heart, and possibly gauging the responsiveness of the cardiovascular system (CVS) to hypoxia, in addition to tumor suppression. Here, we briefly review the latest discoveries on Ecrg4 and its underlying molecular mechanisms as a tumor suppressor and focus on the emerging roles of Ecrg4 in the CVS.
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影响因子：
4.2
作者：
Yoichiro Mori;H. Ishiguro;Y. Kuwabara;M. Kimura;A. Mitsui;H. Kurehara;R. Mori;K. Tomoda;R. Ogawa
通讯作者：
Yoichiro Mori;H. Ishiguro;Y. Kuwabara;M. Kimura;A. Mitsui;H. Kurehara;R. Mori;K. Tomoda;R. Ogawa
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作者：
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
3.5
作者：
Huh, Yun Hyun;Ryu, Je-Hwang;Chun, Jang-Soo
通讯作者：
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影响因子：
7.3
作者：
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通讯作者：
J. Tadross;M. Patterson;K. Suzuki;K. Beale;C. Boughton;Kl Smith;S. Moore;M. Ghatei;S. Bloom