Serotonin Transporter Imaging in Multiple System Atrophy and Parkinson's Disease.
Serotonin Transporter Imaging in Multiple System Atrophy and Parkinson's Disease.
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DOI：
10.1002/mds.29220
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发表时间：
2022-11
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帕金森病（PD）和多系统萎缩（MSA）均表现为脑干5 -羟色胺能核变性，影响多个皮层下和皮层5 -羟色胺能投射。在MSA中，髓质5 -羟色胺能神经元的病理被很好地记录下来，但5 -羟色胺系统在整个大脑其余部分的变化却没有被很好地描述。利用5 -羟色胺转运体[11C]3 -氨基- 4 -（2 -二甲氨基甲基-苯基磺胺基）-苯腈正电子发射断层扫描（PET）比较MSA和PD患者的5 -羟色胺神经支配。我们对18名MSA患者、23名PD患者和16名健康对照者进行了5 -羟色胺转运体PET成像，以探索脑干、皮层下和皮层感兴趣区域的差异。与PD患者相比，MSA患者在髓质、桥中缝、腹侧纹状体、边缘皮层和丘脑区域的血清素转运体分布体积比较低，但在背纹状体、腹侧前扣带或总皮质区域无差异。对照显示，与PD或MSA组相比，皮质5 -羟色胺转运体结合程度更高，但纹状体和其他相关基底神经节区域的5 -羟色胺转运体结合程度较低。msa -帕金森亚型患者（n = 8）和msa -小脑亚型患者（n = 10）在结合方面无区域差异。多个不同感兴趣区域的血清素转运体分布体积比与MSA患者的运动障碍学会统一帕金森病评定量表运动评分的严重程度呈负相关，但与PD患者无关。与PD相比，MSA患者的脑干和部分前脑皮层下区域的血清素能缺陷更为严重，并且MSA特异性与运动障碍的严重程度相关。©2022作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。
Both Parkinson's disease (PD) and multiple system atrophy (MSA) exhibit degeneration of brainstem serotoninergic nuclei, affecting multiple subcortical and cortical serotoninergic projections. In MSA, medullary serotoninergic neuron pathology is well documented, but serotonin system changes throughout the rest of the brain are less well characterized. To use serotonin transporter [11C]3‐amino‐4‐(2‐dimethylaminomethyl‐phenylsulfaryl)‐benzonitrile positron emission tomography (PET) to compare serotoninergic innervation in patients with MSA and PD. We performed serotonin transporter PET imaging in 18 patients with MSA, 23 patients with PD, and 16 healthy controls to explore differences in brainstem, subcortical, and cortical regions of interest. Patients with MSA showed lower serotonin transporter distribution volume ratios compared with patients with PD in the medulla, raphe pontis, ventral striatum, limbic cortex, and thalamic regions, but no differences in the dorsal striatal, ventral anterior cingulate, or total cortical regions. Controls showed greater cortical serotonin transporter binding compared with PD or MSA groups but lower serotonin transporter binding in the striatum and other relevant basal ganglia regions. There were no regional differences in binding between patients with MSA–parkinsonian subtype (n = 8) and patients with MSA–cerebellar subtype (n = 10). Serotonin transporter distribution volume ratios in multiple different regions of interest showed an inverse correlation with the severity of Movement Disorders Society Unified Parkinson's Disease Rating Scale motor score in patients with MSA but not patients with PD. Brainstem and some forebrain subcortical region serotoninergic deficits are more severe in MSA compared with PD and show an MSA‐specific correlation with the severity of motor impairments. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
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