Integrated Analysis of the Functions and Prognostic Values of RNA-Binding Proteins in Colorectal Cancer.
Integrated Analysis of the Functions and Prognostic Values of RNA-Binding Proteins in Colorectal Cancer.
复制标题
RNA结合蛋白在结直肠癌中的功能和预后价值的综合分析
DOI：
10.3389/fcell.2020.595605
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发表时间：
2020
影响因子：
5.5
通讯作者：
Fu K
中科院分区：
文献类型：
--
作者：
Wang Y;Chen Y;Xiao S;Fu K
结直肠癌是最常见的恶性肿瘤之一。由于缺乏足够的生物标志物，为CRC患者选择有效的治疗方法，特别是在早期阶段，仍然是一个挑战。最近的证据表明，RNA结合蛋白（RBP）在癌症的发生和发展中起着至关重要的作用。然而，它们在癌症进展中的机制仍然有限。人们对限制性商业惯例在CRC中的作用知之甚少。使用Wilcoxon检验分析了CRC组织和正常组织之间报告的1，542个RBP，以鉴定差异表达的RBP（DE RBP）。通过系统的生物信息学分析，探讨这些DE RBP的潜在功能和预后价值。在结直肠癌组织和正常组织中鉴定出177个DE RBP。构建了基于DE RBP的蛋白质相互作用网络，筛选出关键模块。构建了预后性DE RBP和差异表达转录因子之间的调控网络。此外，基于预后DE RBP建立了一个风险特征，该风险特征能够以较高的准确性预测CRC患者的总生存期。总之，这些结果提供了对RBP在CRC中的功能的全面理解，以及RBP相关的预后特征。
Colorectal cancer (CRC) is one of the most common malignant tumors. Selecting effective treatment for CRC patients, especially in the early stages, remains a challenge because of the lack of adequate biomarkers. Recent evidence suggests that RNA-binding proteins (RBPs) play a vital role in development and progression of carcinogenesis. However, their mechanisms in cancer progression are still limited. The role of RBPs in CRC has been poorly understood. There were 1,542 reported RBPs analyzed between CRC tissues and normal tissues using the Wilcoxon test to identify differentially expressed RBPs (DE RBPs). Then, the potential functions and the prognostic value of these DE RBPs were explored through systematic bioinformatics analysis. There were 177 DE RBPs identified between CRC tissues and normal tissues. A protein–protein interaction network was constructed based on DE RBPs, and critical modules were screened. A regulatory network between prognostic DE RBPs and differentially expressed transcription factors was constructed. Besides, a risk signature was built based on prognostic DE RBPs, which is able to predict overall survival of CRC patients with high accuracy. In conclusion, the results provided a comprehensive understanding of the functions of RBPs in CRC, as well as an RBP-related prognostic signature.
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影响因子：
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作者：
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通讯作者：
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作者：
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