Flavonoids: A Myth or a Reality for Cancer Therapy?
Flavonoids: A Myth or a Reality for Cancer Therapy?
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DOI：
10.3390/molecules26123583
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发表时间：
2021-06-11
期刊：
影响因子：
--
通讯作者：
Beninati S
中科院分区：
文献类型：
--
作者：
Forni C;Rossi M;Borromeo I;Feriotto G;Platamone G;Tabolacci C;Mischiati C;Beninati S
营养保健品是食品中存在的生物活性分子；它们可以对健康产生有益的影响，但它们的数量不足以发挥这一功能。植物代谢物，例如多酚，广泛分布在植物界中，在植物发育和与环境的相互作用中发挥着重要作用。其中，类黄酮尤其令人感兴趣，因为它们对人类健康具有显着影响。体外和/或体内研究将类黄酮描述为预防多种疾病的必需营养素。它们表现出广泛且有前景的生物活性，可以对抗癌症、炎症、细菌感染，以及减轻神经退行性疾病和心血管疾病或糖尿病的严重程度。因此，近年来人们对类黄酮的兴趣急剧增加也就不足为奇了。过去十年中，超过 23,000 篇有关类黄酮的科学出版物描述了这些天然分子的潜在抗癌活性。体外和体内研究表明，类黄酮具有抗癌特性，许多流行病学研究证实，饮食中摄入类黄酮可以降低患癌症的风险。这篇综述提供了类黄酮对癌细胞作用机制的一瞥。
Nutraceuticals are biologically active molecules present in foods; they can have beneficial effects on health, but they are not available in large enough quantities to perform this function. Plant metabolites, such as polyphenols, are widely diffused in the plant kingdom, where they play fundamental roles in plant development and interactions with the environment. Among these, flavonoids are of particular interest as they have significant effects on human health. In vitro and/or in vivo studies described flavonoids as essential nutrients for preventing several diseases. They display broad and promising bioactivities to fight cancer, inflammation, bacterial infections, as well as to reduce the severity of neurodegenerative and cardiovascular diseases or diabetes. Therefore, it is not surprising that interest in flavonoids has sharply increased in recent years. More than 23,000 scientific publications on flavonoids have described the potential anticancer activity of these natural molecules in the last decade. Studies, in vitro and in vivo, show that flavonoids exhibit anticancer properties, and many epidemiological studies confirm that dietary intake of flavonoids leads to a reduced risk of cancer. This review provides a glimpse of the mechanisms of action of flavonoids on cancer cells.
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作者：
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