Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capability for sentinel lymph node detection.
Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capability for sentinel lymph node detection.
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DOI：
10.1259/bjr.20160435
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Perkins AC
中科院分区：
文献类型：
--
作者：
Alqahtani MS;Lees JE;Bugby SL;Jambi LK;Perkins AC
混合伽马照相机（HGC）已被开发用于在外科手术（如前哨淋巴结（SLN）活检）期间增强靶组织中放射性药物摄取的定位。为了评估HGC的能力，构建了淋巴结造影（LNC）体模，以模拟不同放射性浓度和SLN大小的医学场景。使用两块透明丙烯酸玻璃板构建体模。通过在1个板中的直径范围为10至2.5 mm的圆形威尔斯孔（总共16个威尔斯孔）来模拟SLN。第二个板包含四个较大的矩形威尔斯孔，以模拟SLN周围的组织背景活性。用于模拟每个SLN的活性范围在4和0.025 MBq之间。SLN中注入的本底和活性之间的活性浓度比为1：10。将LNC体模放置在散射材料的不同深度处，范围在5 mm和40 mm之间。准直器到源的距离为120 mm。图像采集时间范围为60 - 240 s。对比噪声比分析和半峰全宽（FWHM）的测量模拟前哨淋巴结进行所获得的图像。在使用的活性范围内，HGC通过20 mm的散射材料检测到87.5%至100%的SLN，通过40 mm的散射材料检测到75%至93.75%的SLN。SLN的FWHM范围为11.93 ~ 14.70 mm。HGC能够检测小SLN中的低活性累积，表明其在外科SLN手术期间作为术中成像系统的有用性。本研究探讨了一种新的小视场（SFOV）HGC检测小SLN低活性摄取的能力。所描述的体模和程序是廉价的，可以很容易地复制和应用到任何SFOV相机，以提供具有临床相关结果的系统之间的比较。
The hybrid gamma camera (HGC) has been developed to enhance the localization of radiopharmaceutical uptake in targeted tissues during surgical procedures such as sentinel lymph node (SLN) biopsy. To assess the capability of the HGC, a lymph node contrast (LNC) phantom was constructed to simulate medical scenarios of varying radioactivity concentrations and SLN size. The phantom was constructed using two clear acrylic glass plates. The SLNs were simulated by circular wells of diameters ranging from 10 to 2.5 mm (16 wells in total) in 1 plate. The second plate contains four larger rectangular wells to simulate tissue background activity surrounding the SLNs. The activity used to simulate each SLN ranged between 4 and 0.025 MBq. The activity concentration ratio between the background and the activity injected in the SLNs was 1 : 10. The LNC phantom was placed at different depths of scattering material ranging between 5 and 40 mm. The collimator-to-source distance was 120 mm. Image acquisition times ranged from 60 to 240 s. Contrast-to-noise ratio analysis and full-width-at-half-maximum (FWHM) measurements of the simulated SLNs were carried out for the images obtained. Over the range of activities used, the HGC detected between 87.5 and 100% of the SLNs through 20 mm of scattering material and 75–93.75% of the SLNs through 40 mm of scattering material. The FWHM of the detected SLNs ranged between 11.93 and 14.70 mm. The HGC is capable of detecting low accumulation of activity in small SLNs, indicating its usefulness as an intraoperative imaging system during surgical SLN procedures. This study investigates the capability of a novel small-field-of-view (SFOV) HGC to detect low activity uptake in small SLNs. The phantom and procedure described are inexpensive and could be easily replicated and applied to any SFOV camera, to provide a comparison between systems with clinically relevant results.
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DOI：
10.1007/s00259-005-1823-y
发表时间：
2005-10-01
影响因子：
9.1
作者：
Kopelman, D;Blevis, I;Hashmonai, M
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DOI：
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2003-03-01
影响因子：
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影响因子：
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DOI：
10.1016/j.ejmp.2013.10.004
发表时间：
2014-05-01
影响因子：
3.4
作者：
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DOI：
10.1016/j.nima.2009.01.181
发表时间：
2009-06-01
影响因子：
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作者：
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Strueder, L.