Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia.
Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia.
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DOI：
10.1016/j.eplepsyres.2014.10.010
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发表时间：
2015-01
影响因子：
2.2
通讯作者：
Epilepsy Phenome/Genome Project Investigators
中科院分区：
文献类型：
--
作者：
Pardoe HR;Mandelstam SA;Hiess RK;Kuzniecky RI;Jackson GD;Alzheimer's Disease Neuroimaging Initiative;Epilepsy Phenome/Genome Project Investigators
我们研究了脑室周围结节性异位（PVNH）胼胝体形态的系统差异。胼胝体中矢状面和次区域面积变化的差异采用自动化软件为基础的方法进行测量。异位灰质沉积自动标记，并与胼胝体的变化进行比较。胼胝体变化的空间模式进行了解释的背景下，在健康个体的胼胝体的前后发展的特点。室周结节性异位的个体在墨尔本脑中心或作为多位点癫痫表型基因组项目的一部分进行成像。对病例组（n = 48）和对照组（n = 663）进行全脑T1加权MRI检查。使用“yuki”软件在正中矢状面上分割胼胝体。使用Freesurfer测量异位灰质和颅内脑体积。胼胝体面积和次区域的差异进行了评估，以及胼胝体面积和异位GM体积之间的关系。胼胝体变化和异位GM结节的前后分布使用一种新的度量进行量化，并相互比较。PVNH患者胼胝体面积减少14%（p = 1.59 × 10−9）。影响的幅度在小脑中最小（减少7%），在峡部和压部最大（减少26%）。具有较高异位GM体积的个体具有较小的胼胝体。异位GM体积在后部脑区最高，但胼胝体前后位置变化与PVNH结节之间没有线性关系。胼胝体面积减少与PVNH密切相关，并且可能与这种神经系统疾病的异常脑发育有关。主要是后部胼胝体的变化可能会告知我们的PVNH的病因的理解。我们的研究结果表明，半球间通路的影响PVNH。
We investigated systematic differences in corpus callosum morphology in periventricular nodular heterotopia (PVNH). Differences in corpus callosum mid-sagittal area and subregional area changes were measured using an automated software-based method. Heterotopic gray matter deposits were automatically labeled and compared with corpus callosum changes. The spatial pattern of corpus callosum changes were interpreted in the context of the characteristic anterior-posterior development of the corpus callosum in healthy individuals. Individuals with periventricular nodular heterotopia were imaged at the Melbourne Brain Center or as part of the multi-site Epilepsy Phenome Genome project. Whole brain T1 weighted MRI was acquired in cases (n = 48) and controls (n = 663). The corpus callosum was segmented on the mid-sagittal plane using the software “yuki”. Heterotopic gray matter and intracranial brain volume was measured using Freesurfer. Differences in corpus callosum area and subregional areas were assessed, as well as the relationship between corpus callosum area and heterotopic GM volume. The anterior-posterior distribution of corpus callosum changes and heterotopic GM nodules were quantified using a novel metric and compared with each other. Corpus callosum area was reduced by 14% in PVNH (p = 1.59 × 10−9). The magnitude of the effect was least in the genu (7% reduction) and greatest in the isthmus and splenium (26% reduction). Individuals with higher heterotopic GM volume had a smaller corpus callosum. Heterotopic GM volume was highest in posterior brain regions, however there was no linear relationship between the anterior-posterior position of corpus callosum changes and PVNH nodules. Reduced corpus callosum area is strongly associated with PVNH, and is probably associated with abnormal brain development in this neurological disorder. The primarily posterior corpus callosum changes may inform our understanding of the etiology of PVNH. Our results suggest that interhemispheric pathways are affected in PVNH.
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影响因子：
5
作者：
BARKOVICH, AJ;NORMAN, D
通讯作者：
NORMAN, D
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
3.5
作者：
Gonzalez, G.;Vedolin, L.;Barkovich, A. J.
通讯作者：
Barkovich, A. J.
DOI：
10.1016/j.yebeh.2009.05.009
发表时间：
2009-08
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Walker LM;Katzir T;Liu T;Ly J;Corriveau K;Barzillai M;Chu F;O'Connor MG;Hackney DB;Chang BS
通讯作者：
Chang BS
影响因子：
2.5
作者：
RAKIC, P;YAKOVLEV, PI
通讯作者：
YAKOVLEV, PI