Predicting (131)I-avidity of metastases from differentiated thyroid cancer using (18)F-FDG PET/CT in postoperative patients with elevated thyroglobulin.
Predicting (131)I-avidity of metastases from differentiated thyroid cancer using (18)F-FDG PET/CT in postoperative patients with elevated thyroglobulin.
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使用 F-18-FDG PET/CT 预测术后甲状腺球蛋白升高患者的分化型甲状腺癌转移灶的 I-131 亲和力
DOI：
10.1038/s41598-018-22656-4
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发表时间：
2018-03-12
影响因子：
4.6
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Liu M;Cheng L;Jin Y;Ruan M;Sheng S;Chen L
分化型甲状腺癌（DTC）转移灶中碘与糖代谢的定量关系尚不清楚。前瞻性研究的目的是建立18F-FDG PET/CT在第一次放射性碘治疗前预测DTC转移的价值。本研究共纳入121例经131I辅助治疗或18F-FDG PET/CT扫描后治疗的血清促甲状腺球蛋白（ssTg）升高的DTC术后患者。建立Receiver工作特性曲线，建立最佳截断点，评价SUVmax对131i贪婪度的预测价值。在我们的研究中，131i -非avid转移靶病变的中位SUVmax也显著高于131I-avid转移靶病变（5.37 vs. 3.30, P = 0.000）。在SUVmax临界值为4.0时，曲线下面积为0.62，敏感性为75.3%，特异性为56.7%，阳性预测值为76.1%，阴性预测值为54.8%。这些结果表明，18F-FDG PET/CT在131I给药前识别ssTg升高的DTC术后患者的转移可能具有重要价值，从而改善疾病管理。SUVmax大于4.0的18F-FDG阳性转移性DTC对放射性碘不贪婪的概率较高。
The quantitative relationship between iodine and glucose metabolism in metastases from differentiated thyroid cancer (DTC) remains unknown. Aim of the prospective study was to establish the value of 18F-FDG PET/CT in predicting 131I-avidity of metastases from DTC before the first radioiodine therapy. A total of 121 postoperative DTC patients with elevated stimulated serum thyroglobulin (ssTg) who underwent 131I adjuvant therapy or therapy after 18F-FDG PET/CT scan were enrolled. The Receiver operating characteristic curve was established to create an optimal cut-off point and evaluate the value of SUVmax for predicting 131I-avidity. In our study, the median SUVmax in 131I-nonavid metastatic target lesions was also significantly higher than that in 131I-avid metastatic target lesions (5.37 vs. 3.30; P = 0.000). At a cut-off value of 4.0 in SUVmax, the area under curve was 0.62 with the sensitivity, specificity, positive predictive value and negative predictive value of 75.3%, 56.7%, 76.1%, and 54.8%, respectively. These results suggest that 18F-FDG PET/CT may be of great value in identifying metastases in postoperative DTC patients with elevated ssTg before 131I administration, leading to an improved management of disease. 18F-FDG positive metastatic DTC with SUVmax of greater than 4.0 possesses higher probability of non-avidity to radioiodine.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
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