Functionalization of halloysite nanotubes by enlargement and hydrophobicity for sustained release of analgesic
Functionalization of halloysite nanotubes by enlargement and hydrophobicity for sustained release of analgesic
复制标题
通过扩大和疏水性对埃洛石纳米管进行功能化以实现镇痛剂的持续释放
DOI：
10.1016/j.colsurfa.2015.09.062
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Shian Zhong
中科院分区：
文献类型：
--
作者：
Hui Li;Xiaohong Zhu;Hui Zhou;Shian Zhong
制备了一种新型疏水性有机-无机杂化纳米复合材料，用于持续释放镇痛剂。使用扩大的埃洛石纳米管（EHNTs）作为纳米容器和有机硅烷（OS）作为疏水层，通过温和的反应很容易制备出表示为EHNTs@OS的纳米复合材料。然后通过傅里叶变换红外光谱、透射电子显微镜、能量色散X射线分析和高效液相色谱对EHNTs@OS进行了表征。由四乙氧基硅烷和辛基三乙氧基硅烷组成的疏水层对EHNTs@OS的润湿性产生影响。结果表明，该纳米复合材料具有优异的疏水性，水接触角为132°。此外，EHNTs@OS 对 IBU 的吸附能力（25%）和缓释性能（100 小时）均得到增强，并且遵循幂律动力学模型。综上所述，本工作探索的药物释放平台适用于其他药物，具有进一步综合应用前景。
A novel hydrophobic organic–inorganic hybrid nanocomposite was prepared for sustained release of analgesic. Using enlarged halloysite nanotubes (EHNTs) as nanocontainer and organosilane (OS) as the hydrophobic layer, nanocomposite denote as EHNTs@OS was readily prepared with a mild reaction. Then the EHNTs@OS was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, and high-performance liquid chromatography. The hydrophobic layer composed of tetraethoxysilane and octyltriethoxysilane made a difference on the wettability of the EHNTs@OS. It was proved that the nanocomposite exhibited excellent hydrophobicity with a water contact angle of 132°. Moreover, an enhanced capacity for adsorption (25%) and the sustained-release performance (100 h) of the EHNTs@OS toward IBU were demonstrated and it followed the power law kinetic model. In conclusion, the drug-release platform explored in this work is suitable for other drugs and shows further comprehensive application prospect.
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