Short-term aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia.
Short-term aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia.
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DOI：
10.2337/dc09-0149
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发表时间：
2009-08
期刊：
影响因子：
16.2
通讯作者：
Meneilly GS
中科院分区：
文献类型：
--
作者：
Madden KM;Lockhart C;Cuff D;Potter TF;Meneilly GS
动脉僵硬增加与心血管死亡率之间的关系在2型糖尿病中得到了很好的证实。我们研究了有氧运动是否可以降低合并高血压和高脂血症的老年2型糖尿病患者的动脉僵硬。共纳入36名老年人(平均年龄71.4±0.7岁)，他们控制饮食或口服降糖控制的2型糖尿病、高血压和高胆固醇血症。受试者被随机分成两组：有氧组(3个月剧烈有氧运动)和非有氧组(不进行有氧运动)。运动课程由一名认证的运动教练监督，每周三次，并结合使用自行车测力计和跑步机。动脉僵硬是使用Complier设备测量的。当两组比较时，有氧训练使两组的脉搏波速度均降低(−20.7±6.3vs.+8.5±6.6%，P=0.005)和股骨脉搏波速度(−13.9±6.7vs.+4.4±3.3%，P=0.015)，尽管有氧能力的VO2max评估与训练没有改善(P=0.026)。我们的发现表明，在老年人中进行相对较短的有氧运动干预可以减少多因素的动脉僵硬(2型糖尿病、衰老、高血压和高胆固醇血症)。
The relationship between increased arterial stiffness and cardiovascular mortality is well established in type 2 diabetes. We examined whether aerobic exercise could reduce arterial stiffness in older adults with type 2 diabetes complicated by comorbid hypertension and hyperlipidemia. A total of 36 older adults (mean age 71.4 ± 0.7 years) with diet-controlled or oral hypoglycemic–controlled type 2 diabetes, hypertension, and hypercholesterolemia were recruited. Subjects were randomly assigned to one of two groups: an aerobic group (3 months vigorous aerobic exercise) and a nonaerobic group (no aerobic exercise). Exercise sessions were supervised by a certified exercise trainer three times per week, and a combination of cycle ergometers and treadmills was used. Arterial stiffness was measured using the Complior device. When the two groups were compared, aerobic training resulted in a decrease in measures of both radial (−20.7 ± 6.3 vs. +8.5 ± 6.6%, P = 0.005) and femoral (−13.9 ± 6.7 vs. +4.4 ± 3.3%, P = 0.015) pulse-wave velocity despite the fact that aerobic fitness as assessed by Vo2max did not demonstrate an improvement with training (P = 0.026). Our findings indicate that a relatively short aerobic exercise intervention in older adults can reduce multifactorial arterial stiffness (type 2 diabetes, aging, hypertension, and hypercholesterolemia).
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影响因子：
8.3
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