Developing a toolkit for the assessment and monitoring of musculoskeletal ageing.
Developing a toolkit for the assessment and monitoring of musculoskeletal ageing.
复制标题
开发一个工具包，以评估和监测肌肉骨骼衰老。
DOI：
10.1093/ageing/afy143
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发表时间：
2018-09-01
期刊：
影响因子：
6.7
通讯作者：
Mathers JC
中科院分区：
文献类型：
--
作者：
Kemp GJ;Birrell F;Clegg PD;Cuthbertson DJ;De Vito G;van Dieën JH;Del Din S;Eastell R;Garnero P;Goljanek-Whysall K;Hackl M;Hodgson R;Jackson MJ;Lord S;Mazzà C;McArdle A;McCloskey EV;Narici M;Peffers MJ;Schiaffino S;Mathers JC
衰老过程的复杂性和异质性减缓了对健康衰老的适当生物标志物达成共识的速度。医学研究委员会-英国关节炎研究肌肉骨骼老化综合研究中心 (CIMA) 是利物浦大学、谢菲尔德大学和纽卡斯尔大学的研究人员和临床医生之间的合作项目。 CIMA 的目标之一是“确定并分享监测所有肌肉骨骼组织与年龄相关的变化的最佳技术和方法，并提供肌肉骨骼功能的综合评估”，换句话说，开发一个评估肌肉骨骼衰老的工具包。该工具包被设想为一种工具，可用于表征和量化“正常”衰老过程中的肌肉骨骼功能，适合在大规模、国际重要的队列中使用，并为旨在增强健康肌肉骨骼衰老的流行病学和干预研究提供一套生物标志物结果测量。这些潜在的生物标志物包括：生物体液或组织样本中的生化测量、身体成分的体内测量、结构和物理特性的成像以及功能测试。本综述评估了这四个标题下的肌肉骨骼衰老候选生物标志物，详细介绍了它们的生物学基础、优点和局限性，并为其使用提出了实用建议。此外，我们还确定了证据基础上的差距以及肌肉骨骼衰老生物标志物进一步研究的优先事项。
The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council–Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA’s objectives is to ‘Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function’—in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during ‘normal’ ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.
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影响因子：
2.9
作者：
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通讯作者：
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作者：
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通讯作者：
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