MicroRNA Profiling in Cartilage Ageing.
MicroRNA Profiling in Cartilage Ageing.
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DOI：
10.1155/2017/2713725
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发表时间：
2017
影响因子：
2.9
通讯作者：
Peffers M
中科院分区：
文献类型：
--
作者：
Balaskas P;Goljanek-Whysall K;Clegg P;Fang Y;Cremers A;Emans P;Welting T;Peffers M
骨关节炎（Osteoarthritis，OA）是人类最常见的与年龄相关的关节疾病，MicroRNA（microRNA，miRNA）是一类小分子非编码RNA，是调节疾病和衰老分子机制的潜在治疗靶点。虽然关于miRNA在衰老中的作用的研究越来越多，但关于软骨中miRNA的年龄相关变化的研究却很少。我们对年轻人和老年人的软骨进行了微阵列研究。研究结果在一个独立的队列中得到验证。这些样品之间的对比鉴定了来自老年供体的软骨中的20种差异表达的miRNA，其源自基于OA严重程度聚类的OA环境。我们鉴定了许多在软骨老化和OA中发生变化的公认和新的miRNA，包括miR-126：一种在OA发病机制中发挥作用的潜在新候选者。这些分析代表了具有作为软骨老化和OA生物标志物和治疗靶点的潜力的重要候选物。
Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets.
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影响因子：
3.5
作者：
Harries LW
通讯作者：
Harries LW
miRNA 在软骨稳态中的作用
影响因子：
2.6
作者：
Li YP;Wei XC;Li PC;Chen CW;Wang XH;Jiao Q;Wang DM;Wei FY;Zhang JZ;Wei L
通讯作者：
Wei L
影响因子：
5.4
作者：
Jin L;Zhao J;Jing W;Yan S;Wang X;Xiao C;Ma B
通讯作者：
Ma B
影响因子：
3.7
作者：
Borgonio Cuadra VM;González-Huerta NC;Romero-Córdoba S;Hidalgo-Miranda A;Miranda-Duarte A
通讯作者：
Miranda-Duarte A
影响因子：
12.7
作者：
Chen D;Shen J;Zhao W;Wang T;Han L;Hamilton JL;Im HJ
通讯作者：
Im HJ