Evaluation of inputs to rat primary auditory cortex from the suprageniculate nucleus and extrastriate visual cortex.
Evaluation of inputs to rat primary auditory cortex from the suprageniculate nucleus and extrastriate visual cortex.
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DOI：
10.1002/cne.22411
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发表时间：
2010-09-15
期刊：
影响因子：
--
通讯作者：
Uhlrich DJ
中科院分区：
文献类型：
--
作者：
Smith PH;Manning KA;Uhlrich DJ
有证据表明，视觉刺激会影响初级听觉皮质的细胞。为了评估这种视觉输入的潜在来源以及它们如何进入听觉皮质的回路，我们研究了初级听觉皮质中来自非初级纹外视觉皮质(V2M，V2L)和来自多模式丘脑膝状体上核(SG)的轴突终末。粗大的生物细胞素/BDA注射到SG或纹外皮质，标记的输入主要终止于浅层和深层。SG主要投射到I、V和VI层，V2M和V2L主要投射到I层和VI层，V2L也投射到II/III层。I层输入的不同之处在于SG终端表面集中，V2L更深，V2M均匀分布。单独的轴突重建表明，单个轴突可以1)支配多层，2)在I层中运行相当远的距离，3)优先在背腹方向上运行，类似于等频轴。在电子显微镜水平上，SG和V2M终末1)大小相同，2)非GABA能，3)小于在第IV层突触的腹侧内侧膝状终末，4)使不对称突触到达树突/棘上，5)非GABA能，6)在第I层略大。因此，这两个区域都提供了实质性的反馈样输入，其差异可能表明潜在的不同作用。
Evidence indicates that visual stimuli influence cells in primary auditory cortex. To evaluate potential sources of this visual input and how they enter into circuitry of the auditory cortex, we examined axonal terminations in primary auditory cortex from non-primary extrastriate visual cortex (V2M, V2L) and from the multimodal thalamic suprageniculate nucleus (SG). Gross biocytin/BDA injections into SG or extrastriate cortex labeled inputs terminating primarily in superficial and deep layers. SG projects primarily to layers I, V and VI, V2M and V2L project primarily to layers I and VI with V2L also targeting layers II/III. Layer I inputs differ in that SG terminals are concentrated superficially, V2L deeper and V2M are equally distributed throughout. Individual axonal reconstructions document that single axons can 1) innervate multiple layers, 2) run considerable distances in layer I, and 3) run preferentially in the dorsoventral direction similar to isofrequency axes. At the electron microscopic level SG and V2M terminals are 1) the same size regardless of layer, 2) non-GABAergic, 3) smaller than ventral medial geniculate terminals synapsing in layer IV and 4) make asymmetric synapses onto dendrites/spines which 5) are non-GABAergic and 6) are slightly larger in layer I. Thus, both areas provide a substantial feedback-like input with differences that may indicate potentially different roles.
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影响因子：
2.5
作者：
BARNES, CL;PANDYA, DN
通讯作者：
PANDYA, DN
影响因子：
2
作者：
Clemo, H. Ruth;Sharma, Giriraj K.;Allman, Brian L.;Meredith, M. Alex
通讯作者：
Meredith, M. Alex
DOI：
10.1523/jneurosci.2093-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barbour DL;Callaway EM
通讯作者：
Callaway EM
影响因子：
2.5
作者：
CLERICI, WJ;COLEMAN, JR
通讯作者：
COLEMAN, JR
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN