Successful acceptance of adult liver allografts by intra-bone marrow-bone marrow transplantation.
Successful acceptance of adult liver allografts by intra-bone marrow-bone marrow transplantation.
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骨髓内-骨髓移植成功接受成人同种异体肝移植。
DOI：
10.1089/scd.2007.0218
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发表时间：
2008
影响因子：
4
通讯作者：
S. Ikehara
中科院分区：
文献类型：
--
作者：
S. Okazaki;H. Hisha;T. Mizokami;T. Takaki;Xiao;Chang;Qing Li;J. Kato;Y. Kamiyama;S. Ikehara
此前，我们已经证明，当共同移植来自同一品系的成年小鼠的骨髓细胞（BMC）时，从胎儿或幼年小鼠获得的同种异体肝脏移植物是可以被接受的。然而，对于临床实际应用，从同一成年供体获得骨髓细胞和肝脏更为方便。 C57BL/6 小鼠接受单次高剂量照射或两次低剂量照射，并静脉注射 (IV-BMT) 供体 BALB/c（8 周龄）BMC 或直接注射到受体 BM 腔内 (IBM-BMT)。同一天，取自同一捐献者的肝组织被移植到肾被膜下。与 IV-BMT 组相比，IBM-BMT 组实现了更高的存活率和更完整的供体细胞重建，两种照射方案都是如此。在所有用供体型细胞取代血淋巴细胞的小鼠中都观察到供体肝组织的接受。重建小鼠的肝移植物形态正常，抗白蛋白抗体和高碘酸希夫（PAs）染色呈阳性，表明移植肝已被接受、已生长且具有功能。这些结果表明，通过 IBM 途径共移植供体 BMC 可以实现同种异体肝脏的接受。
Previously, we have shown that liver allografts obtained from the fetus or young mice are accepted when bone marrow cells (BMCs) from adult mice of the same strain are co-grafted. However, for practical clinical use, it is more convenient to obtain both BMCs and liver from the same adult donors. C57BL/6 mice were irradiated with a single high-dose irradiation or two low-dose irradiations and injected with donor BALB/c (8 weeks old) BMCs intravenously (IV-BMT) or directly into the recipient BM cavity (IBM-BMT). Liver tissues taken from the same donor were, on the same day, engrafted under the kidney capsules. Higher survival rates and more complete reconstitution of donor cells were achieved in the IBM-BMT group than in the IV-BMT group, and this was the case in both irradiation protocols. The acceptance of donor liver tissue was seen in all mice in which hematolymphoid cells were replaced by donor-type cells. The liver grafts of the reconstituted mice showed normal morphology and stained positively with anti-albumin antibody and Periodic Acid Schiff (PAs) staining, indicating that the grafted livers were accepted, had grown, and were functioning. These results demonstrate that the acceptance of allogeneic liver can be achieved by cografting donor BMCs via the IBM route.
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DOI：
10.1002/hep.1840040720
发表时间：
1984
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Russell,PS
通讯作者：
Russell,PS
小鼠同种异体胰腺移植与骨髓移植联合成功。
影响因子：
6.4
作者：
Iwai,H;Yasumizu,R;Sugiura,K;Inaba,M;Kumazawa,T;Good,RA;Ikehara,S
通讯作者：
Ikehara,S
通过与同种异体骨髓移植相结合，在小鼠体内成功进行同种异体肝脏移植。
DOI：
10.1073/pnas.83.12.4529
发表时间：
1986
影响因子：
11.1
作者：
Nakamura,T;Good,RA;Yasumizu,R;Inoue,S;Oo,MM;Hamashima,Y;Ikehara,S
通讯作者：
Ikehara,S
在没有 TCR 参与的情况下，IL-4 增强小鼠 Th2 细胞中 IL-10 基因的表达。
DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Schmidt-Weber,CB;Alexander,SI;Henault,LE;James,L;Lichtman,AH
通讯作者：
Lichtman,AH