Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults.
Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults.
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作者：
Taaffe DR;Henwood TR;Nalls MA;Walker DG;Lang TF;Harris TB
骨骼肌老化的特征不仅在于尺寸（肌肉减少症）和强度的减小，而且还在于脂肪浸润（肌脂肪变性）的增加。抗阻运动是肌少症的有效对策，但其对脂肪浸润的影响尚不清楚。为了检查在阻力训练的老年人，如果肌肉衰减，反映肌内脂质含量的肌肉密度的非侵入性措施，是改变与训练状态。13名年龄在65-83岁的健康社区居民男性和女性（BMI，27.0 ± 1.2 kg/m2，平均值± SE）在24周的训练、24周的停训和12周的再训练后进行了大腿中部的计算机断层扫描。训练和再训练每周进行两次，几个上部和下部的身体肌肉群。获得了股四头肌和腿筋的亨氏单位（HU）以及大腿中部肌肉体积的骨骼肌衰减。肌肉力量通过1次重复最大值进行评估，身体功能通过一组测试进行评估。在训练、停止训练和再训练后，肌肉力量的平均变化分别为48.8 ± 2.9%、−17.6 ± 1.3%和19.8 ± 2.0%。力量变化伴随着肌肉密度的显著变化（p < 0.001），四头肌HU在停止训练后下降7.7 ± 1.0%，在再训练后增加5.4 ± 0.5%。对于腘绳肌HU测量，停止训练和再训练分别导致11.9 ± 1.4%的损失和5.5 ± 1.8%的增益。肌肉体积无显著变化。停止抗阻训练的老年人增加肌肉的脂肪浸润，而恢复运动减少it. Monitoring在肌肉大小和脂肪浸润的变化，可以提供一个更全面的评估运动在打击与年龄相关的肌肉变化。
Aging skeletal muscle is characterized by not only a reduction in size (sarcopenia) and strength but also by an increase in fatty infiltration (myosteatosis). An effective countermeasure to sarcopenia is resistance exercise; however, its effect on fatty infiltration is less clear. To examine in resistance trained older persons if muscle attenuation, a noninvasive measure of muscle density reflecting intramuscular lipid content, is altered with training status. Thirteen healthy community-dwelling men and women aged 65–83 years (BMI, 27.0 ± 1.2 kg/m2, mean ± SE) had computed tomography scans of the mid-thigh performed following 24 weeks training, 24 weeks detraining, and 12 weeks retraining. Training and retraining were undertaken twice weekly for several upper and lower body muscle groups. Skeletal muscle attenuation in Hounsfield Units (HU) as well as mid-thigh muscle volume was obtained for the quadriceps and hamstrings. Muscle strength was assessed by 1-repetition maximum and physical function by a battery of tests. The average change in muscle strength following training, detraining, and retraining was 48.8 ± 2.9%, −17.6 ± 1.3%, and 19.8 ± 2.0%, respectively. Strength changes were accompanied by significant alterations in muscle density (p < 0.001), with the quadriceps HU decreasing by 7.7 ± 1.0% following detraining and increasing by 5.4 ± 0.5% with retraining. For the hamstrings HU measure, detraining and retraining resulted in a 11.9 ± 1.4% loss and a 5.5 ± 1.8% gain, respectively. There was no significant change in muscle volume. Cessation of resistance exercise in trained older persons increases the fatty infiltration of muscle while resumption of exercise decreases it. Monitoring changes in both muscle size and fat infiltration may provide for a more comprehensive assessment of exercise in combating age-related muscular changes.
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DOI：
10.1111/j.1475-097x.1981.tb00876.x
发表时间：
1981-01-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
ANIANSSON, A;GUSTAFSSON, E
通讯作者：
GUSTAFSSON, E
影响因子：
13.2
作者：
Cheema, Bobby;Abas, Haifa;Singh, Maria Fiatarone
通讯作者：
Singh, Maria Fiatarone
影响因子：
3.3
作者：
PRATLEY, R;NICKLAS, B;GOLDBERG, A
通讯作者：
GOLDBERG, A
影响因子：
5.8
作者：
PYKA, G;WISWELL, RA;MARCUS, R
通讯作者：
MARCUS, R
影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB