Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system.
Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system.
复制标题
DOI：
10.1016/j.conb.2009.07.015
复制
发表时间：
2009-06
影响因子：
5.7
通讯作者：
Vosshall LB
中科院分区：
文献类型：
--
作者：
Nakagawa T;Vosshall LB
There is broad consensus that olfactory signalling in vertebrates and the nematode C. elegans uses canonical G protein-coupled receptor transduction pathways. In contrast, mechanisms of insect olfactory signal transduction remain deeply controversial. Genetic disruption of G proteins and chemosensory ion channels in mice and worms leads to profound impairment in olfaction, while similar mutations in the fly show more subtle phenotypes. The literature contains contradictory claims that insect olfaction uses cAMP, cGMP, or IP3 as second messengers; that insect odorant receptors couple to Gαs or Gαq pathways; and that insect odorant receptors are GPCRs or odor-gated ion channels. Here we consider all the evidence and offer a consensus model for a non-canonical mechanism of olfactory signal transduction in insects.
登录
查看更多内容
影响因子：
9.8
作者：
Benton, Richard;Sachse, Silke;Michnick, Stephen W;Vosshall, Leslie B
通讯作者：
Vosshall, Leslie B
影响因子：
56.9
作者：
JONES, DT;REED, RR
通讯作者：
REED, RR
DOI：
10.1046/j.1432-1033.2002.02863.x
发表时间：
2002-04-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Jacquin-Joly, E;François, MC;Maida, R
通讯作者：
Maida, R
影响因子：
3.6
作者：
Laue, M;Maida, R;Redkozubov, A
通讯作者：
Redkozubov, A
影响因子：
16.2
作者：
Larsson, MC;Domingos, AI;Vosshall, LB
通讯作者：
Vosshall, LB