Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes.
Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes.
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DOI：
10.1001/archneur.65.12.1621
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发表时间：
2008-12
影响因子：
--
通讯作者：
Jack, Clifford R., Jr.
中科院分区：
文献类型：
--
作者：
Kantarci, Kejal;Petersen, Ronald C.;Przybelski, Scott A.;Weigand, Stephen D.;Shiung, Maria M.;Whitwell, Jennifer L.;Negash, Selamawit;Ivnik, Robert J.;Boeve, Bradley F.;Knopman, David S.;Smith, Glenn E.;Jack, Clifford R., Jr.
虽然大多数遗忘型轻度认知障碍（aMCI）患者进展为阿尔茨海默病，但非遗忘型MCI（naMCI）的自然史尚不清楚。MCI潜在病理学发现的非侵入性成像替代物将在临床上用于识别可能受益于痴呆前驱期疾病特异性治疗的患者。探讨MCI各亚型的磁共振成像（MRI）和质子磁共振波谱（1H MRS）特征。病例对照研究。三级转诊中心的社区样本。91例单域aMCI患者、32例多域aMCI患者、20例单域或多域naMCI患者和100例认知正常的老年受试者，按年龄和性别进行频率匹配。MRI上后扣带回1H MRS代谢物比率、海马体积和脑血管疾病单域aMCI患者的特点是海马体积小，肌醇与肌酸水平的比值升高。平均而言，naMCI患者的海马体积和1H MRS代谢物比率正常，但与单域aMCI患者（91例中的6例[7%]）相比，更大比例（20例患者中的3例[15%]）发生皮质梗死。对于MCI亚型的表征，1H MRS和结构MRI结果是互补的。单域aMCI的MRI和1HMRS表现与阿尔茨海默病相似。在naMCI患者中平均缺乏这种模式表明，脑血管疾病和其他神经退行性疾病可能导致许多naMCI患者的认知障碍。
Although a majority of patients with amnestic mild cognitive impairment (aMCI) progress to Alzheimer disease, the natural history of nonamnestic MCI (naMCI) is less clear. Noninvasive imaging surrogates for underlying pathological findings in MCI would be clinically useful for identifying patients who may benefit from disease-specific treatments at the prodromal stage of dementia. To determine the characteristic magnetic resonance imaging (MRI) and proton MR spectroscopy (1H MRS) profiles of MCI subtypes. Case-control study. Community-based sample at a tertiary referral center. Ninety-one patients with single-domain aMCI, 32 patients with multiple-domain aMCI, 20 patients with single- or multiple-domain naMCI, and 100 cognitively normal elderly subjects frequency-matched by age and sex. Posterior cingulate gyrus 1H MRS metabolite ratios, hippocampal volumes, and cerebrovascular disease on MRI. Patients with single-domain aMCI were characterized by small hippocampal volumes and elevated ratios of myo-inositol to creatine levels. Patients with naMCI on average had normal hippocampal volumes and 1H MRS metabolite ratios, but a greater proportion (3 of 20 patients [15%]) had cortical infarctions compared with patients with single-domain aMCI (6 of 91 [7%]). For characterization of MCI subtypes, 1H MRS and structural MRI findings were complementary. The MRI and 1H MRS findings in singledomain aMCI are consistent with a pattern similar to that of Alzheimer disease. Absence of this pattern on average in patients with naMCI suggests that cerebrovascular disease and other neurodegenerative diseases may be contributing to the cognitive impairment in many individuals with naMCI.
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影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
8.3
作者：
Bombois, Stephanie;Debette, Stephanie;Pasquier, Florence
通讯作者：
Pasquier, Florence
影响因子：
9.9
作者：
FLICKER, C;FERRIS, SH;REISBERG, B
通讯作者：
REISBERG, B
影响因子：
9.9
作者：
Busse, A.;Hensel, A.;Riedel-Heller, S. G.
通讯作者：
Riedel-Heller, S. G.
影响因子：
9.9
作者：
Josephs, K. A.;Whitwell, J. L.;Petersen, R. C.
通讯作者：
Petersen, R. C.