Effect of intrauterine fetal programming on response to postnatal shaker stress in endothelial nitric oxide knockout mouse model.
Effect of intrauterine fetal programming on response to postnatal shaker stress in endothelial nitric oxide knockout mouse model.
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DOI：
10.1016/j.ajog.2009.05.040
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发表时间：
2009-09
影响因子：
9.8
通讯作者：
Longo M
中科院分区：
文献类型：
--
作者：
Costantine MM;Ferrari F;Chiossi G;Tamayo E;Hankins GD;Saade GR;Longo M
To determine whether the intrauterine environment affects the postnatal vascular response to stress in a model of fetal programming induced by endothelial nitric oxide synthase (NOS3) deficiency. Homozygous NOS3 knockout and wild type controls were cross-bred to obtain maternally- (KOM) and paternally- (KOP) derived heterozygous offspring. At 14 weeks of age, in-vivo blood pressure (BP) measurements by telemetry, and in-vitro carotid arteries vascular reactivity studies were performed in male offspring after subjecting them to shaker stress. KOM offspring, compared to KOP, had significantly higher systolic BP, mean arterial BP and pulse pressure before, as well as after introduction of the shaker stress. The difference in the latter between KOM and KOP was accentuated after stress. KOM offspring also had significantly higher contractile responses to phenylephrine when compared to KOP, and this was abolished after incubation with L-NAME. The adverse uterine environment affects the postnatal vascular response to stress
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影响因子：
15.9
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通讯作者：
Shaul, PW
影响因子：
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Jeanclos, E;Schork, NJ;Aviv, A
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Aviv, A
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Aviv, A
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Tan, EQ;Gurjar, MV;Bhalla, RC
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Bhalla, RC
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Bernatova, I;Key, MP;Morris, M
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Morris, M